Scly MGI Mouse Gene Detail - MGI:1355310

Symbol

Scly
Name

selenocysteine lyase
Synonyms

A930015N15Rik, SCL, Scly1, Scly2, Selenocysteine reductase

Feature Type

protein coding gene
IDs

MGI:1355310
NCBI Gene: 50880
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr1:91226060-91248797 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 46.08 cM
Mapping Data

2 experiments

SNPs within 2kb

749 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1355310	protein coding gene	Chr1:91226017-91248797 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016304	protein coding gene	Chr1:92837052-92862189 (+)
A/J	MGP_AJ_G0016285	protein coding gene	Chr1:89491227-89514333 (+)
AKR/J	MGP_AKRJ_G0016246	protein coding gene	Chr1:92152427-92175117 (+)
BALB/cJ	MGP_BALBcJ_G0016241	protein coding gene	Chr1:89678476-89701559 (+)
C3H/HeJ	MGP_C3HHeJ_G0016070	protein coding gene	Chr1:92369579-92394335 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016700	protein coding gene	Chr1:96398100-96423847 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014418	protein coding gene	Chr1:83749011-83771694 (+)
CAST/EiJ	MGP_CASTEiJ_G0015655	protein coding gene	Chr1:91713299-91739641 (+)
CBA/J	MGP_CBAJ_G0016046	protein coding gene	Chr1:99482793-99508536 (+)
DBA/2J	MGP_DBA2J_G0016149	protein coding gene	Chr1:88718822-88742435 (+)
FVB/NJ	MGP_FVBNJ_G0016148	protein coding gene	Chr1:87749798-87776062 (+)
LP/J	MGP_LPJ_G0016220	protein coding gene	Chr1:93994857-94020520 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016173	protein coding gene	Chr1:102726646-102751078 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016740	protein coding gene	Chr1:92176322-92199008 (+)
PWK/PhJ	MGP_PWKPhJ_G0015439	protein coding gene	Chr1:88135195-88158937 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015222	protein coding gene	Chr1:91099355-91122185 (+)
WSB/EiJ	MGP_WSBEiJ_G0015713	protein coding gene	Chr1:91973445-91996156 (+)

Human Ortholog

SCLY, selenocysteine lyase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SCLY, selenocysteine lyase
Synonyms

hSCL, SCL
Links

HGNC:18161

NCBI Gene ID: 51540

neXtProt AC: NX_Q96I15

UniProt: Q96I15
Chr Location

2q37.3; chr2:238060924-238099413 (+) GRCh38

MGI Vertebrate Homology

Scly stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SCLY
Protein SuperFamily

NifS
Gene Tree

Scly

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
13 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Chemically induced (other)

1
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Scly
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available

Mice fed a selenium-deficient diet exhibit mild learning impairment.

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All GO Annotations

15
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

800
Tissues

94
cDNA Data

9
Literature Summary

1

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase scly

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All Sequences

81
RefSeq

15
UniProt

8
CCDS

CCDS15159.1

Ensembl

ENSMUSG00000026307 (Evidence)
NCBI Gene

50880

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026307	Ensembl Gene Model \| MGI Sequence Detail	22738	C57BL/6J	± kb
transcript	ENSMUST00000027532	Ensembl \| MGI Sequence Detail	2202	Not Applicable
polypeptide	ENSMUSP00000027532	Ensembl \| MGI Sequence Detail	432	Not Applicable

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UniProt

8 Sequences
Protein Ontology

PR:000014517 selenocysteine lyase

(term hierarchy)
EC

4.4.1.16
InterPro Domains

IPR000192 Aminotransferase class V domain

IPR016454 Cysteine desulfurase

IPR015424 Pyridoxal phosphate-dependent transferase

IPR015421 Pyridoxal phosphate-dependent transferase, major domain

IPR015422 Pyridoxal phosphate-dependent transferase, small domain

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All nucleic 9

cDNA 9

Microarray probesets 4

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MGI:1925207

Summaries

All 42

Developmental Gene Expression 1

Gene Ontology 7

Phenotypes 13
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:290754 Torres DJ, et al., Agrp-Specific Ablation of Scly Protects against Diet-Induced Obesity and Leptin Resistance. Nutrients. 2019 Jul 23;11(7)

TSS for Scly:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr8070	Chr1:91226056-91226075 (+)	6 bp
Tssr8071	Chr1:91226076-91226113 (+)	35 bp
Tssr8072	Chr1:91233893-91233896 (+)	7,835 bp
Tssr8073	Chr1:91236340-91236349 (+)	10,285 bp
Tssr8074	Chr1:91236355-91236364 (+)	10,300 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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