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Tnfrsf19 Gene Detail
Summary
  • Symbol
    Tnfrsf19
  • Name
    tumor necrosis factor receptor superfamily, member 19
  • Synonyms
    TAJ, TAJ-ALPHA, TRADE, Troy
  • Feature Type
    protein coding gene
  • IDs
    MGI:1352474
    NCBI Gene: 29820
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:61201324-61283939 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 32.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2143 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1352474
 protein coding gene Chr14:61201283-61284304 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021436
 protein coding gene Chr14:55317177-55406979 (-)
A/J MGP_AJ_G0021395
 protein coding gene Chr14:54106599-54196279 (-)
AKR/J MGP_AKRJ_G0021370
 protein coding gene Chr14:56035620-56129099 (-)
BALB/cJ MGP_BALBcJ_G0021400
 protein coding gene Chr14:54068447-54152107 (-)
C3H/HeJ MGP_C3HHeJ_G0021178
 protein coding gene Chr14:55694174-55782967 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021839
 protein coding gene Chr14:58037320-58126517 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019379
 protein coding gene Chr14:52128548-52217953 (-)
CAST/EiJ MGP_CASTEiJ_G0020694
 protein coding gene Chr14:52083609-52172721 (-)
CBA/J MGP_CBAJ_G0021145
 protein coding gene Chr14:59685773-59784825 (-)
DBA/2J MGP_DBA2J_G0021268
 protein coding gene Chr14:53792277-53875480 (-)
FVB/NJ MGP_FVBNJ_G0021246
 protein coding gene Chr14:53209364-53292770 (-)
LP/J MGP_LPJ_G0021342
 protein coding gene Chr14:56366273-56451916 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021275
 protein coding gene Chr14:59032119-59117815 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021862
 protein coding gene Chr14:55204214-55292748 (-)
PWK/PhJ MGP_PWKPhJ_G0020438
 protein coding gene Chr14:50455872-50541117 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020271
 protein coding gene Chr14:51136127-51232155 (-)
WSB/EiJ MGP_WSBEiJ_G0020747
 protein coding gene Chr14:55507887-55597774 (-)



Homology
more
  • Human Ortholog
    TNFRSF19, TNF receptor superfamily member 19
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNFRSF19, TNF receptor superfamily member 19
  • Synonyms
    TAJ, TAJ-alpha, TRADE, TROY
  • Links
    NCBI Gene ID: 55504
    neXtProt AC: NX_Q9NS68
    UniProt: Q9NS68

  • Chr Location
    13q12.12; chr13:23570370-23676104 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotypes from multigenic genotypes
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice exhibit no obvious physical abnormalities or alterations in behavior, locomotion, or fecundity, however neurons are more resistant to the suppressive action of myelin inhibitors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    12
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    986
  • Tissues
    129
  • cDNA Data
    22
  • Literature Summary
    31
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000060548 Ensembl Gene Model | MGI Sequence Detail 82616 C57BL/6J ±  kb
transcript ENSMUST00000111236 Ensembl | MGI Sequence Detail 3958 Not Applicable  
polypeptide ENSMUSP00000106867 Ensembl | MGI Sequence Detail 416 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000016483 tumor necrosis factor receptor superfamily member 19
    (term hierarchy)
  • InterPro Domains
    IPR001368 TNFR/NGFR cysteine-rich region
    IPR034047 Tumor necrosis factor receptor 19, N-terminal
    IPR047526 Tumor necrosis factor receptor superfamily member 19/27/EDAR
    IPR022342 Tumour necrosis factor receptor 19
  • GlyGen
    Q9JLL3 2 sites, 2 N-linked glycans (2 sites)
Molecular
Reagents
less
  • All nucleic 29
    cDNA 22
    Primer pair 4
    Other 3

    Microarray probesets 6
Other
Accession IDs
less
MGI:1890132, MGI:2145715, MGI:2145803
References
more
  • Summaries
    All 75
    Developmental Gene Expression 31
    Gene Ontology 6
    Phenotypes 17
  • Earliest
    J:58926 Hu S, et al., Characterization of TNFRSF19, a novel member of the tumor necrosis factor receptor superfamily. Genomics. 1999 Nov 15;62(1):103-7
  • Latest
    J:348841 Grommisch D, et al., Defining the contribution of Troy-positive progenitor cells to the mouse esophageal epithelium. Dev Cell. 2024 May 20;59(10):1269-1283.e6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/22/2024
MGI 6.24 		The Jackson Laboratory