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Adam28 Gene Detail
Summary
  • Symbol
    Adam28
  • Name
    a disintegrin and metallopeptidase domain 28
  • Synonyms
    C130072N01Rik, D430033C21Rik, Dtgn1, MDC-L
  • Feature Type
    protein coding gene
  • IDs
    MGI:105988
    NCBI Gene: 13522
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:68843476-68893291 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 35.69 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1704 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_105988
 protein coding gene Chr14:68842447-68893338 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021512
 protein coding gene Chr14:63376429-63426671 (-)
A/J MGP_AJ_G0021471
 protein coding gene Chr14:61854925-61906531 (-)
AKR/J MGP_AKRJ_G0021447
 protein coding gene Chr14:63945595-63996137 (-)
BALB/cJ MGP_BALBcJ_G0021477
 protein coding gene Chr14:61841078-61890553 (-)
C3H/HeJ MGP_C3HHeJ_G0021254
 protein coding gene Chr14:63694429-63745655 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021916
 protein coding gene Chr14:66251304-66300807 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019456
 protein coding gene Chr14:59734441-59787895 (-)
CAST/EiJ MGP_CASTEiJ_G0020771
 protein coding gene Chr14:60203037-60254686 (-)
CBA/J MGP_CBAJ_G0021221
 protein coding gene Chr14:68283382-68335641 (-)
DBA/2J MGP_DBA2J_G0021344
 protein coding gene Chr14:61473600-61525500 (-)
FVB/NJ MGP_FVBNJ_G0021323
 protein coding gene Chr14:60880891-60930384 (-)
LP/J MGP_LPJ_G0021419
 protein coding gene Chr14:64441720-64500468 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021352
 protein coding gene Chr14:67251044-67302499 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021939
 protein coding gene Chr14:63189283-63244618 (-)
PWK/PhJ MGP_PWKPhJ_G0020515
 protein coding gene Chr14:58228621-58280431 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020348
 protein coding gene Chr14:59120196-59179668 (-)
WSB/EiJ MGP_WSBEiJ_G0020824
 protein coding gene Chr14:63507889-63562337 (-)



Homology
more
  • Human Ortholog
    ADAM28, ADAM metallopeptidase domain 28
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAM28, ADAM metallopeptidase domain 28
  • Synonyms
    ADAM 28, eMDC II, eMDCII, MDC-L, MDCL
  • Links
    NCBI Gene ID: 10863
    neXtProt AC: NX_Q9UKQ2
    UniProt: Q9UKQ2

  • Chr Location
    8p21.2; chr8:24294069-24359014 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with human ADAM28 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout increases metastatic pulmonary colonization after injection with tumor cells as a result of reduced pulmonary CD8+ T cell invasion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    774
  • Tissues
    32
  • cDNA Data
    10
  • Literature Summary
    2
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000014725 Ensembl Gene Model | MGI Sequence Detail 49816 C57BL/6J ±  kb
transcript ENSMUST00000022642 Ensembl | MGI Sequence Detail 3110 Not Applicable  
polypeptide ENSMUSP00000022642 Ensembl | MGI Sequence Detail 793 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    cDNA 11
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-33668, MGI:2442612, MGI:2443863
References
more
  • Summaries
    All 41
    Developmental Gene Expression 2
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:30468 Weskamp G, et al., A family of cellular proteins related to snake venom disintegrins. Proc Natl Acad Sci U S A. 1994 Mar 29;91(7):2748-51
  • Latest
    J:290452 Kiyozumi D, et al., NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility. Science. 2020 Jun 5;368(6495):1132-1135
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory