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Socs6 Gene Detail
Summary
  • Symbol
    Socs6
  • Name
    suppressor of cytokine signaling 6
  • Synonyms
    1500012M23Rik, 5830401B18Rik, CIS4, Cish4, HSPC060, Socs4, SOCS-4, SOCS-6, SSI4, STAI4, STAT4, STATI4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1924885
    NCBI Gene: 54607
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:88883293-88912623 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 58.66 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    588 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1924885
 protein coding gene Chr18:88683348-88945605 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024615
 protein coding gene Chr18:89990905-90273039 (-)
A/J MGP_AJ_G0024582
 protein coding gene Chr18:85979280-86211956 (-)
AKR/J MGP_AKRJ_G0024553
 protein coding gene Chr18:88574885-88846485 (-)
BALB/cJ MGP_BALBcJ_G0024580
 protein coding gene Chr18:86246688-86517413 (-)
C3H/HeJ MGP_C3HHeJ_G0024349
 protein coding gene Chr18:88711804-88988428 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025028
 protein coding gene Chr18:92293773-92567864 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022458
 protein coding gene Chr18:84745494-84965374 (-)
CAST/EiJ MGP_CASTEiJ_G0020945
 protein coding gene Chr15:1164722-1169314 (+)
CBA/J MGP_CBAJ_G0024319
 protein coding gene Chr18:95590778-95870003 (-)
DBA/2J MGP_DBA2J_G0024448
 protein coding gene Chr18:85546979-85804003 (-)
FVB/NJ MGP_FVBNJ_G0024415
 protein coding gene Chr18:84865476-85125760 (-)
LP/J MGP_LPJ_G0024533
 protein coding gene Chr18:89878768-90141373 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024445
 protein coding gene Chr18:97388841-97690207 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025076
 protein coding gene Chr18:88867098-89130252 (-)
PWK/PhJ MGP_PWKPhJ_G0023567
 protein coding gene Chr18:85883811-86162486 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023374
 protein coding gene Chr18:88819211-89069549 (-)
WSB/EiJ MGP_WSBEiJ_G0023884
 protein coding gene Chr18:88777510-89003826 (-)



Homology
more
  • Human Ortholog
    SOCS6, suppressor of cytokine signaling 6
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SOCS6, suppressor of cytokine signaling 6
  • Synonyms
    CIS-4, CIS4, HSPC060, SOCS-4, SOCS4, SOCS-6, SSI4, STAI4, STATI4
  • Links
    NCBI Gene ID: 9306
    neXtProt AC: NX_O14544
    UniProt: O14544

  • Chr Location
    18q22.2; chr18:70289045-70330199 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted null mutation exhibit reduced body weight, but normal hematopoiesis and glucose homeostasis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    748
  • Tissues
    12
  • cDNA Data
    20
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 54607 NCBI Gene Model | MGI Sequence Detail 29331 C57BL/6J ±  kb
    transcript NM_018821 RefSeq | MGI Sequence Detail 5921 C57BL/6  
    polypeptide Q9JLY0 UniProt | EBI | MGI Sequence Detail 533 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 20
      Primer pair 3

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1916217, MGI:2147224
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 11
    • Earliest
      J:51029 Hilton DJ, et al., Twenty proteins containing a C-terminal SOCS box form five structural classes. Proc Natl Acad Sci U S A. 1998 Jan 6;95(1):114-9
    • Latest
      J:257927 Fairchild CL, et al., RBX2 maintains final retinal cell position in a DAB1-dependent and -independent fashion. Development. 2018 Feb 2;145(3):dev155283
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory