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Pias4 Gene Detail
Summary
  • Symbol
    Pias4
  • Name
    protein inhibitor of activated STAT 4
  • Synonyms
    PIASy
  • Feature Type
    protein coding gene
  • IDs
    MGI:2136940
    NCBI Gene: 59004
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:80989795-81003554 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM, cytoband C1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    242 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2136940
 protein coding gene Chr10:80989100-81003757 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017538
 protein coding gene Chr10:81846805-81861457 (-)
A/J MGP_AJ_G0017516
 protein coding gene Chr10:78949959-78965702 (-)
AKR/J MGP_AKRJ_G0017477
 protein coding gene Chr10:81122219-81138504 (-)
BALB/cJ MGP_BALBcJ_G0017478
 protein coding gene Chr10:79165574-79181403 (-)
C3H/HeJ MGP_C3HHeJ_G0017301
 protein coding gene Chr10:81204817-81219402 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017932
 protein coding gene Chr10:84649288-84663879 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015621
 protein coding gene Chr10:75152321-75166897 (-)
CAST/EiJ MGP_CASTEiJ_G0016868
 protein coding gene Chr10:81442467-81456911 (-)
CBA/J MGP_CBAJ_G0017273
 protein coding gene Chr10:87949033-87963634 (-)
DBA/2J MGP_DBA2J_G0017379
 protein coding gene Chr10:78146053-78162510 (-)
FVB/NJ MGP_FVBNJ_G0017373
 protein coding gene Chr10:77396729-77414965 (-)
LP/J MGP_LPJ_G0017450
 protein coding gene Chr10:82292287-82308149 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017399
 protein coding gene Chr10:89817211-89833153 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017973
 protein coding gene Chr10:81110133-81124784 (-)
PWK/PhJ MGP_PWKPhJ_G0016649
 protein coding gene Chr10:78048941-78063418 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016439
 protein coding gene Chr10:80066701-80081239 (-)
WSB/EiJ MGP_WSBEiJ_G0016928
 protein coding gene Chr10:81147701-81162171 (-)



Homology
more
  • Human Ortholog
    PIAS4, protein inhibitor of activated STAT 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PIAS4, protein inhibitor of activated STAT 4
  • Synonyms
    Piasg, PIAS-gamma, PIASY, ZMIZ6
  • Links
    NCBI Gene ID: 51588
    neXtProt AC: NX_Q8N2W9
    UniProt: Q8N2W9

  • Chr Location
    19p13.3; chr19:4007736-4039386 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 3 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants display mild postnatal lethality or a normal phenotype depending on strain background.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    798
  • Tissues
    91
  • cDNA Data
    78
  • Literature Summary
    11
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 59004 NCBI Gene Model | MGI Sequence Detail 13760 C57BL/6J ±  kb
transcript NM_021501 RefSeq | MGI Sequence Detail 1676 FVB/N  
polypeptide Q9JM05 UniProt | EBI | MGI Sequence Detail 507 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 84
    cDNA 78
    Primer pair 5
    Other 1

    Microarray probesets 5
References
more
  • Summaries
    All 68
    Developmental Gene Expression 11
    Gene Ontology 15
    Phenotypes 13
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:305400 Wu Y, et al., Maternal UHRF1 Is Essential for Transcription Landscapes and Repression of Repetitive Elements During the Maternal-to-Zygotic Transition. Front Cell Dev Biol. 2020;8:610773
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/05/2024
MGI 6.24 		The Jackson Laboratory