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Cdc42ep4 Gene Detail
Summary
  • Symbol
    Cdc42ep4
  • Name
    CDC42 effector protein 4
  • Synonyms
    1500041M20Rik, Borg4, CEP4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929760
    NCBI Gene: 56699
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:113617676-113642707 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 79.22 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    916 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929760
 protein coding gene Chr11:113617676-113643369 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019354
 protein coding gene Chr11:117557246-117586791 (-)
A/J MGP_AJ_G0019323
 protein coding gene Chr11:112495401-112520075 (-)
AKR/J MGP_AKRJ_G0019291
 protein coding gene Chr11:115806577-115831608 (-)
BALB/cJ MGP_BALBcJ_G0019296
 protein coding gene Chr11:112904706-112930189 (-)
C3H/HeJ MGP_C3HHeJ_G0019105
 protein coding gene Chr11:116160332-116186003 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019747
 protein coding gene Chr11:121087691-121115430 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017370
 protein coding gene Chr11:109572082-109597066 (-)
CAST/EiJ MGP_CASTEiJ_G0018659
 protein coding gene Chr11:117434843-117461157 (-)
CBA/J MGP_CBAJ_G0019075
 protein coding gene Chr11:126015892-126040574 (-)
DBA/2J MGP_DBA2J_G0019187
 protein coding gene Chr11:111931839-111957283 (-)
FVB/NJ MGP_FVBNJ_G0019178
 protein coding gene Chr11:111409888-111435181 (-)
LP/J MGP_LPJ_G0019257
 protein coding gene Chr11:117999996-118025653 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019209
 protein coding gene Chr11:125171004-125196896 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019784
 protein coding gene Chr11:116461225-116488354 (-)
PWK/PhJ MGP_PWKPhJ_G0018424
 protein coding gene Chr11:113144429-113169980 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018216
 protein coding gene Chr11:116271449-116296553 (-)
WSB/EiJ MGP_WSBEiJ_G0018711
 protein coding gene Chr11:116421385-116448503 (-)



Homology
more
  • Human Ortholog
    CDC42EP4, CDC42 effector protein 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDC42EP4, CDC42 effector protein 4
  • Synonyms
    BORG4, CEP4, KAIA1777
  • Links
    NCBI Gene ID: 23580
    neXtProt AC: NX_Q9H3Q1
    UniProt: Q9H3Q1

  • Chr Location
    17q25.1; chr17:73283624-73312005 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display impaired glutamate clearance and motor learning.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    29
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    858
  • Tissues
    56
  • cDNA Data
    142
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041598 Ensembl Gene Model | MGI Sequence Detail 25032 C57BL/6J ±  kb
transcript ENSMUST00000106616 Ensembl | MGI Sequence Detail 3405 Not Applicable  
polypeptide ENSMUSP00000102227 Ensembl | MGI Sequence Detail 349 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 143
    cDNA 143

    Microarray probesets 4
Other
Accession IDs
less
MGI:1919259
References
more
  • Summaries
    All 48
    Developmental Gene Expression 7
    Gene Ontology 6
    Phenotypes 14
  • Earliest
    J:65159 Joberty G, et al., The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. Mol Cell Biol. 1999 Oct;19(10):6585-97
  • Latest
    J:325730 Ahuja N, et al., Endothelial Cyp26b1 restrains murine heart valve growth during development. Dev Biol. 2022 Jun;486:81-95
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory