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Csnk1e Gene Detail
Summary
  • Symbol
    Csnk1e
  • Name
    casein kinase 1, epsilon
  • Synonyms
    CK1epsilon, CKI epsilon, CKIepsilon, KC1epsilon, tau
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351660
    NCBI Gene: 27373
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:79302056-79339767 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 37.71 cM, cytoband E1
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    978 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351660
 protein coding gene Chr15:79302054-79339779 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022074
 protein coding gene Chr15:79683609-79711769 (-)
A/J MGP_AJ_G0022035
 protein coding gene Chr15:76939942-76965954 (-)
AKR/J MGP_AKRJ_G0022010
 protein coding gene Chr15:79088542-79114559 (-)
BALB/cJ MGP_BALBcJ_G0022041
 protein coding gene Chr15:76931241-76957981 (-)
C3H/HeJ MGP_C3HHeJ_G0021812
 protein coding gene Chr15:79079018-79105044 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022484
 protein coding gene Chr15:82836388-82864180 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020014
 protein coding gene Chr15:73419707-73445888 (-)
CAST/EiJ MGP_CASTEiJ_G0021333
 protein coding gene Chr15:79782054-79808582 (-)
CBA/J MGP_CBAJ_G0021777
 protein coding gene Chr15:85405381-85435592 (-)
DBA/2J MGP_DBA2J_G0021906
 protein coding gene Chr15:76420883-76447232 (-)
FVB/NJ MGP_FVBNJ_G0021884
 protein coding gene Chr15:75452422-75478404 (-)
LP/J MGP_LPJ_G0021974
 protein coding gene Chr15:79873224-79900478 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021904
 protein coding gene Chr15:90517062-90543051 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022498
 protein coding gene Chr15:79099715-79125928 (-)
PWK/PhJ MGP_PWKPhJ_G0021075
 protein coding gene Chr15:76431817-76458655 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020912
 protein coding gene Chr15:78916587-78943295 (-)
WSB/EiJ MGP_WSBEiJ_G0021385
 protein coding gene Chr15:79483722-79511672 (-)



Homology
more
  • Human Ortholog
    CSNK1E, casein kinase 1 epsilon
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CSNK1E, casein kinase 1 epsilon
  • Synonyms
    CKIe, CKIepsilon, HCKIE
  • Links
    NCBI Gene ID: 1454
    neXtProt AC: NX_P49674
    UniProt: P49674

  • Chr Location
    22q13.1; chr22:38290691-38318084 (-)  GRCh38
  • Human Ortholog
    TPTEP2-CSNK1E, TPTEP2-CSNK1E readthrough
  • Synonyms
    LOC400927-CSNK1E
  • Links
    NCBI Gene ID: 102800317
    neXtProt AC: NX_P49674

  • Chr Location
    22q13.1; chr22:38290691-38398915 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human CSNK1E associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 3 alleles in 2 genetic backgrounds
    54 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit disruptions in circadian rhythms.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    68
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    995
  • Tissues
    183
  • cDNA Data
    135
  • Literature Summary
    10
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022433 Ensembl Gene Model | MGI Sequence Detail 37712 C57BL/6J ±  kb
transcript ENSMUST00000117786 Ensembl | MGI Sequence Detail 2695 Not Applicable  
polypeptide ENSMUSP00000113341 Ensembl | MGI Sequence Detail 416 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 137
    cDNA 136
    Primer pair 1

    Microarray probesets 8
Other
Accession IDs
less
MGI:2145998, MGI:2146039, MGI:2146216
References
more
  • Summaries
    All 122
    Developmental Gene Expression 10
    Diseases 1
    Gene Ontology 24
    Phenotypes 54
  • Earliest
    J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
  • Latest
    J:308263 Maywood ES, et al., Circadian Chimeric Mice Reveal an Interplay Between the Suprachiasmatic Nucleus and Local Brain Clocks in the Control of Sleep and Memory. Front Neurosci. 2021;15:639281
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory