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Polk Gene Detail
Summary
  • Symbol
    Polk
  • Name
    polymerase (DNA directed), kappa
  • Synonyms
    Dinb1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1349767
    NCBI Gene: 27015
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:96617198-96679087 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 13, 50.56 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1875 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1349767
protein coding gene Chr13:96617195-96679087 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020850
protein coding gene Chr13:98016847-98083570 (-)
A/J MGP_AJ_G0020804
protein coding gene Chr13:94326118-94388965 (-)
AKR/J MGP_AKRJ_G0020778
protein coding gene Chr13:97208119-97273978 (-)
BALB/cJ MGP_BALBcJ_G0020801
protein coding gene Chr13:95026422-95088151 (-)
C3H/HeJ MGP_C3HHeJ_G0020594
protein coding gene Chr13:96903497-96969522 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021236
protein coding gene Chr13:100990712-101056604 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018805
protein coding gene Chr13:90127245-90190291 (-)
CAST/EiJ MGP_CASTEiJ_G0020112
protein coding gene Chr13:96229362-96294968 (-)
CBA/J MGP_CBAJ_G0020553
protein coding gene Chr13:104992963-105060422 (-)
DBA/2J MGP_DBA2J_G0020678
protein coding gene Chr13:94103247-94165637 (-)
FVB/NJ MGP_FVBNJ_G0020659
protein coding gene Chr13:92865488-92928450 (-)
LP/J MGP_LPJ_G0020753
protein coding gene Chr13:98153456-98217983 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020687
protein coding gene Chr13:105374665-105438518 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021277
protein coding gene Chr13:96627119-96699046 (-)
PWK/PhJ MGP_PWKPhJ_G0019864
protein coding gene Chr13:92887251-92950344 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019688
protein coding gene Chr13:92917224-92984170 (-)
WSB/EiJ MGP_WSBEiJ_G0020169
protein coding gene Chr13:97111460-97176926 (-)



Homology
more
  • Human Ortholog
    POLK, DNA polymerase kappa
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    POLK, DNA polymerase kappa
  • Synonyms
    DINB1, DINP, POLQ
  • Links
    NCBI Gene ID: 51426
    neXtProt AC: NX_Q9UBT6
    UniProt: Q9UBT6

  • Chr Location
    5q13.3; chr5:75510774-75609991 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 3 genetic backgrounds
    1 phenotype from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene that results in a truncated transcript results in a higher rate of spontaneous germline expanded simple tandem repeat mutations. Homozyogus null mice exhibit normal immunoglobulin gene somatic hypermutation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021668 Ensembl Gene Model | MGI Sequence Detail 61890 C57BL/6J ±  kb
transcript ENSMUST00000022172 Ensembl | MGI Sequence Detail 4225 Not Applicable  
polypeptide ENSMUSP00000022172 Ensembl | MGI Sequence Detail 852 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 41
    cDNA 37
    Primer pair 4

    Microarray probesets 5
References
more
  • Summaries
    All 54
    Developmental Gene Expression 2
    Gene Ontology 9
    Phenotypes 18
  • Earliest
    J:58083 Gerlach VL, et al., Human and mouse homologs of Escherichia coli DinB (DNA polymerase IV), members of the UmuC/DinB superfamily. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11922-7
  • Latest
    J:348075 Shah P, et al., Primordial germ cell DNA demethylation and development require DNA translesion synthesis. Nat Commun. 2024 May 3;15(1):3734

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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last database update
11/05/2024
MGI 6.24
The Jackson Laboratory