Rasgrp2 MGI Mouse Gene Detail - MGI:1333849 - RAS, guanyl releasing protein 2

Symbol

Rasgrp2
Name

RAS, guanyl releasing protein 2
Synonyms

Caldaggef1, CalDAG-GEFI

Feature Type

protein coding gene
IDs

MGI:1333849
NCBI Gene: 19395
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr19:6449370-6465246 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 4.58 cM, cytoband A
Mapping Data

1 experiment

SNPs within 2kb

176 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1333849	protein coding gene	Chr19:6449038-6465246 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0024763	protein coding gene	Chr19:3454636-3471965 (+)
A/J	MGP_AJ_G0024729	protein coding gene	Chr19:3265995-3281867 (+)
AKR/J	MGP_AKRJ_G0024702	protein coding gene	Chr19:3363321-3379224 (+)
BALB/cJ	MGP_BALBcJ_G0024729	protein coding gene	Chr19:3263256-3279167 (+)
C3H/HeJ	MGP_C3HHeJ_G0024497	protein coding gene	Chr19:3383855-3399735 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0025175	protein coding gene	Chr19:3505973-3521853 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022609	protein coding gene	Chr19:3188950-3204809 (+)
CAST/EiJ	MGP_CASTEiJ_G0023969	protein coding gene	Chr19:3409378-3425252 (+)
CBA/J	MGP_CBAJ_G0024469	protein coding gene	Chr19:3677507-3693372 (+)
DBA/2J	MGP_DBA2J_G0024596	protein coding gene	Chr19:3253544-3269418 (+)
FVB/NJ	MGP_FVBNJ_G0024562	protein coding gene	Chr19:3270239-3286107 (+)
LP/J	MGP_LPJ_G0024682	protein coding gene	Chr19:3419089-3435001 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024591	protein coding gene	Chr19:3501135-3516898 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025223	protein coding gene	Chr19:3388476-3404351 (+)
PWK/PhJ	MGP_PWKPhJ_G0023715	protein coding gene	Chr19:3288004-3304005 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0023520	protein coding gene	Chr19:3347554-3363528 (+)
WSB/EiJ	MGP_WSBEiJ_G0024031	protein coding gene	Chr19:3403194-3420396 (+)

Human Ortholog

RASGRP2, RAS guanyl releasing protein 2

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RASGRP2, RAS guanyl releasing protein 2
Synonyms

CALDAG-GEFI, CDC25L
Links

HGNC:9879

NCBI Gene ID: 10235

neXtProt AC: NX_Q7LDG7

UniProt: Q7LDG7
Chr Location

11q13.1; chr11:64726911-64745456 (-) GRCh38

MGI Vertebrate Homology

Rasgrp2 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RASGRP2
Gene Tree

Rasgrp2

Diseases

1 with Rasgrp2 mouse models; 1 with human RASGRP2 associations

Human Disease

Mouse Models

leukocyte adhesion deficiency 3

IDs

View 1 model

platelet-type bleeding disorder 18

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

less

Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
2 phenotypes from multigenic genotypes
26 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

28
Endonuclease-mediated

1
Gene trapped

23
Targeted

4
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

47 strains or lines available

Mice homozygous for a knock-out allele do not undergo spontaneous hemorrhaging but exhibit impaired platelet aggregation, resistance to collagen-induced thrombosis, and increased bleeding times after tail transection.

less

All GO Annotations

18
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

710
Tissues

4
cDNA Data

9
Literature Summary

6

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

less

All Sequences

137
RefSeq

54
UniProt

9
CCDS

CCDS37898.1, CCDS89325.1

Ensembl

ENSMUSG00000032946 (Evidence)
NCBI Gene

19395

			Length	Strain/Species	Flank
genomic	ENSMUSG00000032946	Ensembl Gene Model \| MGI Sequence Detail	15877	C57BL/6J	± kb
transcript	ENSMUST00000113476	Ensembl \| MGI Sequence Detail	2296	Not Applicable
polypeptide	ENSMUSP00000109104	Ensembl \| MGI Sequence Detail	608	Not Applicable

less

UniProt

9 Sequences
Protein Ontology

PR:000013759 RAS guanyl-releasing protein 2

(term hierarchy)
InterPro Domains

IPR046349 C1-like domain superfamily

IPR018247 EF-Hand 1, calcium-binding site

IPR002048 EF-hand domain

IPR011992 EF-hand domain pair

IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain

IPR036964 Ras guanine-nucleotide exchange factor, catalytic domain superfamily

IPR023578 Ras guanine nucleotide exchange factor domain superfamily

IPR001895 Ras guanine-nucleotide exchange factors catalytic domain

IPR008937 Ras-like guanine nucleotide exchange factor

IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal

less

All nucleic 12

cDNA 9

Primer pair 3

Microarray probesets 6

Summaries

All 63

Developmental Gene Expression 6

Diseases 1

Gene Ontology 7

Phenotypes 26
Earliest

J:52725 Kedra D, et al., The germinal center kinase gene and a novel CDC25-like gene are located in the vicinity of the PYGM gene on 11q13. Hum Genet. 1997 Oct;100(5-6):611-9
Latest

J:322215 Crittenden JR, et al., CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors. Neurobiol Dis. 2021 Oct;158:105473

TSS for Rasgrp2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr154650	Chr19:6447670-6447689 (+)	-1,690 bp
Tssr154651	Chr19:6448170-6448185 (+)	-1,192 bp
Tssr5424	Chr19:6448767-6448794 (+)	-589 bp
Tssr154652	Chr19:6449865-6449885 (+)	505 bp
Tssr154653	Chr19:6449887-6449920 (+)	534 bp
Tssr154654	Chr19:6450553-6450589 (+)	1,201 bp
Tssr154655	Chr19:6450641-6450652 (+)	1,277 bp
Tssr154656	Chr19:6451705-6451745 (+)	2,355 bp
Tssr154657	Chr19:6458429-6458440 (+)	9,065 bp
Tssr154658	Chr19:6463101-6463117 (+)	13,739 bp
Tssr154659	Chr19:6463135-6463160 (+)	13,778 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 12/17/2024 MGI 6.24