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Psma6 Gene Detail
Summary
  • Symbol
    Psma6
  • Name
    proteasome subunit alpha 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1347006
    NCBI Gene: 26443
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:55431007-55465239 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 23.94 cM, cytoband C1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    958 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1347006
 protein coding gene Chr12:55431007-55465244 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019748
 protein coding gene Chr12:54426283-54462119 (+)
A/J MGP_AJ_G0019707
 protein coding gene Chr12:52462360-52497671 (+)
AKR/J MGP_AKRJ_G0019682
 protein coding gene Chr12:54133560-54172070 (+)
BALB/cJ MGP_BALBcJ_G0019687
 protein coding gene Chr12:52836725-52871572 (+)
C3H/HeJ MGP_C3HHeJ_G0019492
 protein coding gene Chr12:54190977-54227137 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020139
 protein coding gene Chr12:56052678-56092507 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017759
 protein coding gene Chr12:50975083-51009217 (+)
CAST/EiJ MGP_CASTEiJ_G0019044
 protein coding gene Chr12:49042733-49084523 (+)
CBA/J MGP_CBAJ_G0019461
 protein coding gene Chr12:58017773-58073474 (+)
DBA/2J MGP_DBA2J_G0019577
 protein coding gene Chr12:52390158-52424368 (+)
FVB/NJ MGP_FVBNJ_G0019565
 protein coding gene Chr12:51686444-51721393 (+)
LP/J MGP_LPJ_G0019649
 protein coding gene Chr12:54421702-54459822 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019603
 protein coding gene Chr12:59601735-59638523 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020173
 protein coding gene Chr12:53573048-53609967 (+)
PWK/PhJ MGP_PWKPhJ_G0018811
 protein coding gene Chr12:46735505-46770521 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018604
 protein coding gene Chr12:47977202-48016398 (+)
WSB/EiJ MGP_WSBEiJ_G0019095
 protein coding gene Chr12:54083275-54124349 (+)



Homology
more
  • Human Ortholog
    PSMA6, proteasome 20S subunit alpha 6
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PSMA6, proteasome 20S subunit alpha 6
  • Synonyms
    IOTA, p27K, PROS27
  • Links
    NCBI Gene ID: 5687
    neXtProt AC: NX_P60900
    UniProt: P60900

  • Chr Location
    14q13.2; chr14:35278558-35317493 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PSMA6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    735
  • Tissues
    29
  • cDNA Data
    241
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000021024 Ensembl Gene Model | MGI Sequence Detail 34233 C57BL/6J ±  kb
transcript ENSMUST00000021412 Ensembl | MGI Sequence Detail 1042 Not Applicable  
polypeptide ENSMUSP00000021412 Ensembl | MGI Sequence Detail 246 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 241
    cDNA 241

    Microarray probesets 3
References
more
  • Summaries
    All 41
    Developmental Gene Expression 4
    Gene Ontology 11
    Phenotypes 9
  • Earliest
    J:57232 Elenich LA, et al., The complete primary structure of mouse 20S proteasomes. Immunogenetics. 1999 Sep;49(10):835-42
  • Latest
    J:354587 Nedomova M, et al., DDI2 protease controls embryonic development and inflammation via TCF11/NRF1. iScience. 2024 Oct 18;27(10):110893
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory