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Srcin1 Gene Detail
Summary
  • Symbol
    Srcin1
  • Name
    SRC kinase signaling inhibitor 1
  • Synonyms
    mKIAA1684, P140, p140Cap
  • Feature Type
    protein coding gene
  • IDs
    MGI:1933179
    NCBI Gene: 56013
  • Alliance
    gene page
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:97400166-97466059 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 61.00 cM, cytoband D
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    1652 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1933179
 protein coding gene Chr11:97400166-97467012 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019033
 protein coding gene Chr11:99942870-100018927 (-)
A/J MGP_AJ_G0019001
 protein coding gene Chr11:95826685-95892738 (-)
AKR/J MGP_AKRJ_G0018971
 protein coding gene Chr11:98806339-98872392 (-)
BALB/cJ MGP_BALBcJ_G0018974
 protein coding gene Chr11:96315144-96382369 (-)
C3H/HeJ MGP_C3HHeJ_G0018788
 protein coding gene Chr11:98921922-98988535 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019426
 protein coding gene Chr11:103039083-103111204 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017057
 protein coding gene Chr11:93286531-93353549 (-)
CAST/EiJ MGP_CASTEiJ_G0018341
 protein coding gene Chr11:99782581-99851777 (-)
CBA/J MGP_CBAJ_G0018759
 protein coding gene Chr11:107281100-107358458 (-)
DBA/2J MGP_DBA2J_G0018867
 protein coding gene Chr11:95381991-95448440 (-)
FVB/NJ MGP_FVBNJ_G0018856
 protein coding gene Chr11:94872267-94941455 (-)
LP/J MGP_LPJ_G0018937
 protein coding gene Chr11:100451931-100528659 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018883
 protein coding gene Chr11:107143430-107213879 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019466
 protein coding gene Chr11:99102444-99171413 (-)
PWK/PhJ MGP_PWKPhJ_G0018113
 protein coding gene Chr11:96364826-96431773 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017903
 protein coding gene Chr11:98811570-98883772 (-)
WSB/EiJ MGP_WSBEiJ_G0018391
 protein coding gene Chr11:99006357-99074670 (-)



Homology
more
  • Human Ortholog
    SRCIN1, SRC kinase signaling inhibitor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRCIN1, SRC kinase signaling inhibitor 1
  • Synonyms
    P140, SNIP
  • Links
    NCBI Gene ID: 80725
    neXtProt AC: NX_Q9C0H9
    UniProt: Q9C0H9

  • Chr Location
    17q12; chr17:38530031-38607025 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display abnormalities in object recognition memory and motor learning, dendritic spine disorganization, impaired synaptic plasticity, and reduced long term potentiation and long term depression.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    49
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    744
  • Tissues
    34
  • cDNA Data
    18
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56013 NCBI Gene Model | MGI Sequence Detail 65894 C57BL/6J ±  kb
    transcript NM_018873 RefSeq | MGI Sequence Detail 6965 C57BL/6  
    polypeptide Q9QWI6 UniProt | EBI | MGI Sequence Detail 1250 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000012187 SRC kinase signaling inhibitor 1
      (term hierarchy)
    • InterPro Domains
      IPR022782 Actin interacting protein 3-like, C-terminal
      IPR051825 SRC Kinase Signaling Inhibitor
    • GlyGen
      Q9QWI6 13 sites, 1 N-linked glycan (2 sites), 1 O-linked glycan (11 sites)
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 6
      Gene Ontology 12
      Phenotypes 19
    • Earliest
      J:56548 Zheng B, et al., Engineering a mouse balancer chromosome. Nat Genet. 1999 Aug;22(4):375-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory