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Tinf2 Gene Detail
Summary
  • Symbol
    Tinf2
  • Name
    Terf1 (TRF1)-interacting nuclear factor 2
  • Synonyms
    D14Wsu146e, TIN2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107246
    NCBI Gene: 28113
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:55912146-55919277 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    226 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107246
 protein coding gene Chr14:55912120-55919277 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021363
 protein coding gene Chr14:49721977-49724711 (-)
A/J MGP_AJ_G0021322
 protein coding gene Chr14:48728853-48731587 (-)
AKR/J MGP_AKRJ_G0021298
 protein coding gene Chr14:50476412-50479146 (-)
BALB/cJ MGP_BALBcJ_G0021326
 protein coding gene Chr14:48689970-48692704 (-)
C3H/HeJ MGP_C3HHeJ_G0021106
 protein coding gene Chr14:50160572-50163306 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021764
 protein coding gene Chr14:52211050-52213784 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019311
 protein coding gene Chr14:47101044-47103924 (-)
CAST/EiJ MGP_CASTEiJ_G0020625
 protein coding gene Chr14:46429261-46431998 (-)
CBA/J MGP_CBAJ_G0021073
 protein coding gene Chr14:53779284-53782018 (-)
DBA/2J MGP_DBA2J_G0021194
 protein coding gene Chr14:48452048-48454782 (-)
FVB/NJ MGP_FVBNJ_G0021176
 protein coding gene Chr14:47900382-47903116 (-)
LP/J MGP_LPJ_G0021268
 protein coding gene Chr14:50767961-50770695 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021200
 protein coding gene Chr14:53133452-53136186 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021791
 protein coding gene Chr14:49664328-49667062 (-)
PWK/PhJ MGP_PWKPhJ_G0020372
 protein coding gene Chr14:44984991-44987726 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020200
 protein coding gene Chr14:45670268-45672988 (-)
WSB/EiJ MGP_WSBEiJ_G0020678
 protein coding gene Chr14:49948915-49951655 (-)



Homology
more
  • Human Ortholog
    TINF2, TERF1 interacting nuclear factor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TINF2, TERF1 interacting nuclear factor 2
  • Synonyms
    DKCA3, TIN2
  • Links
    NCBI Gene ID: 26277
    neXtProt AC: NX_Q9BSI4
    UniProt: Q9BSI4

  • Chr Location
    14q12; chr14:24238286-24242674 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tinf2 mouse models; 2 with human TINF2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted disruption of this gene results in embryonic lethality prior to E7.5 through a mechanism that is independent of telomerase function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    25
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    821
  • Tissues
    40
  • cDNA Data
    100
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000007589 Ensembl Gene Model | MGI Sequence Detail 7132 C57BL/6J ±  kb
    transcript ENSMUST00000227842 Ensembl | MGI Sequence Detail 2001 Not Applicable  
    polypeptide ENSMUSP00000154628 Ensembl | MGI Sequence Detail 419 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 102
      cDNA 100
      Primer pair 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-35711, MGI:2145835
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 6
      Diseases 1
      Gene Ontology 7
      Phenotypes 12
    • Earliest
      J:50869 Ko MSH, et al., Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Hum Mol Genet. 1998 Nov;7(12):1967-78
    • Latest
      J:325498 Yin S, et al., TIN2 deficiency leads to ALT-associated phenotypes and differentiation defects in embryonic stem cells. Stem Cell Reports. 2022 May 10;17(5):1183-1197
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory