Rdh11 MGI Mouse Gene Detail - MGI:102581 - retinol dehydrogenase 11

Symbol

Rdh11
Name

retinol dehydrogenase 11
Synonyms

2610319N22Rik, Arsdr1, M42C60, Mdt1, Psdr1

Feature Type

protein coding gene
IDs

MGI:102581
NCBI Gene: 17252
Alliance

gene page
Transcription Start Sites

9 TSS

Sequence Map

Chr12:79221007-79238629 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 35.51 cM
Mapping Data

3 experiments

SNPs within 2kb

573 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_102581	protein coding gene	Chr12:79221007-79239067 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0019881	protein coding gene	Chr12:79454522-79474836 (-)
A/J	MGP_AJ_G0019839	protein coding gene	Chr12:76599918-76618735 (-)
AKR/J	MGP_AKRJ_G0019814	protein coding gene	Chr12:78672835-78690689 (-)
BALB/cJ	MGP_BALBcJ_G0019818	protein coding gene	Chr12:76853803-76872031 (-)
C3H/HeJ	MGP_C3HHeJ_G0019624	protein coding gene	Chr12:79151123-79170060 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0020270	protein coding gene	Chr12:81803575-81823225 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017889	protein coding gene	Chr12:73616008-73634799 (-)
CAST/EiJ	MGP_CASTEiJ_G0019174	protein coding gene	Chr12:73982262-74001474 (-)
CBA/J	MGP_CBAJ_G0019595	protein coding gene	Chr12:84997970-85017216 (-)
DBA/2J	MGP_DBA2J_G0019710	protein coding gene	Chr12:76222861-76241376 (-)
FVB/NJ	MGP_FVBNJ_G0019696	protein coding gene	Chr12:75035675-75053544 (-)
LP/J	MGP_LPJ_G0019782	protein coding gene	Chr12:79389656-79408110 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019735	protein coding gene	Chr12:88035002-88053043 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020305	protein coding gene	Chr12:78190422-78211680 (-)
PWK/PhJ	MGP_PWKPhJ_G0018940	protein coding gene	Chr12:70582806-70601821 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0018734	protein coding gene	Chr12:72692429-72710349 (-)
WSB/EiJ	MGP_WSBEiJ_G0019227	protein coding gene	Chr12:78807871-78828824 (-)

Human Ortholog

RDH11, retinol dehydrogenase 11

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

RDH11, retinol dehydrogenase 11
Synonyms

ARSDR1, CGI82, HCBP12, MDT1, PSDR1, RALR1, RDJCSS, SCALD, SDR7C1
Links

HGNC:17964

NCBI Gene ID: 51109

neXtProt AC: NX_Q8TC12

UniProt: Q8TC12
Chr Location

14q24.1; chr14:67676800-67695793 (-) GRCh38

MGI Vertebrate Homology

Rdh11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: RDH11
Gene Tree

Rdh11

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Phenotype Summary

2 phenotypes from 2 alleles in 2 genetic backgrounds
2 phenotypes from multigenic genotypes
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

2
Targeted

5
Genomic Mutations

1 involving Rdh11
Incidental Mutations

APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene exhibit delayed dark adaptation.

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All GO Annotations

16
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

873
Tissues

141
cDNA Data

104
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase rdh11

ZFIN rdh12

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All Sequences

57
RefSeq

6
UniProt

4
CCDS

CCDS36480.1, CCDS88359.1

Ensembl

ENSMUSG00000066441 (Evidence)
NCBI Gene

17252

			Length	Strain/Species	Flank
genomic	17252	NCBI Gene Model \| MGI Sequence Detail	17623	C57BL/6J	± kb
transcript	NM_001362269	RefSeq \| MGI Sequence Detail	2991	ZRU/MplStud
polypeptide	Q9QYF1	UniProt \| EBI \| MGI Sequence Detail	316	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000013849 retinol dehydrogenase 11

(term hierarchy)
EC

1.1.1.300
InterPro Domains

IPR036291 NAD(P)-binding domain superfamily

IPR002347 Short-chain dehydrogenase/reductase SDR

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All nucleic 107

cDNA 104

Primer pair 2

Other 1

Microarray probesets 3

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MGD-MRK-19467, MGI:1914425, MGI:2144817, MGI:2144969, MGI:2145121

Summaries

All 51

Developmental Gene Expression 7

Gene Ontology 8

Phenotypes 15
Earliest

J:19094 Hara T, et al., Characterization of cell phenotype by a novel cDNA library subtraction system: expression of CD8 alpha in a mast cell-derived interleukin-4-dependent cell line. Blood. 1994 Jul 1;84(1):189-99
Latest

J:348785 Zhang D, et al., Maternal Ezh1/2 deficiency impairs the function of mitochondria in mouse oocytes and early embryos. J Cell Physiol. 2024 Mar 26;

TSS for Rdh11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr116834	Chr12:79239022-79239058 (-)	-411 bp
Tssr116833	Chr12:79238987-79239016 (-)	-373 bp
Tssr116832	Chr12:79238975-79238984 (-)	-351 bp
Tssr116831	Chr12:79238649-79238663 (-)	-27 bp
Tssr116830	Chr12:79238613-79238635 (-)	5 bp
Tssr116829	Chr12:79238586-79238606 (-)	33 bp
Tssr116828	Chr12:79237729-79237750 (-)	889 bp
Tssr116827	Chr12:79232482-79232509 (-)	6,133 bp
Tssr116826	Chr12:79222654-79222672 (-)	15,966 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24