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Hs6st3 Gene Detail
Summary
  • Symbol
    Hs6st3
  • Name
    heparan sulfate 6-O-sulfotransferase 3
  • Synonyms
    6OST3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354960
    NCBI Gene: 50787
  • Alliance
    gene page
  • Transcription Start Sites
    24 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:119375753-120107227 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 62.67 cM, cytoband E4
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    21766 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354960
 protein coding gene Chr14:119374902-120226864 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021655
 protein coding gene Chr14:116780387-117558444 (+)
A/J MGP_AJ_G0021615
 protein coding gene Chr14:112308909-113054552 (+)
AKR/J MGP_AKRJ_G0021591
 protein coding gene Chr14:115960283-116718804 (+)
BALB/cJ MGP_BALBcJ_G0021621
 protein coding gene Chr14:112862007-113604179 (+)
C3H/HeJ MGP_C3HHeJ_G0021399
 protein coding gene Chr14:115849452-116601164 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022061
 protein coding gene Chr14:121304093-122112669 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019599
 protein coding gene Chr14:108336831-109031512 (+)
CAST/EiJ MGP_CASTEiJ_G0020914
 protein coding gene Chr14:113716141-114476494 (+)
CBA/J MGP_CBAJ_G0021367
 protein coding gene Chr14:125940491-126786964 (+)
DBA/2J MGP_DBA2J_G0021490
 protein coding gene Chr14:112224666-112951845 (+)
FVB/NJ MGP_FVBNJ_G0021468
 protein coding gene Chr14:110547733-111258835 (+)
LP/J MGP_LPJ_G0021558
 protein coding gene Chr14:117807179-118564965 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021495
 protein coding gene Chr14:131005890-131847531 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022084
 protein coding gene Chr14:115447796-116238243 (+)
PWK/PhJ MGP_PWKPhJ_G0020658
 protein coding gene Chr14:109252252-109976485 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020496
 protein coding gene Chr14:111693992-112468629 (+)
WSB/EiJ MGP_WSBEiJ_G0020970
 protein coding gene Chr14:116218775-116973132 (+)



Homology
more
  • Human Ortholog
    HS6ST3, heparan sulfate 6-O-sulfotransferase 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HS6ST3, heparan sulfate 6-O-sulfotransferase 3
  • Synonyms
    HS6ST-3
  • Links
    NCBI Gene ID: 266722
    neXtProt AC: NX_Q8IZP7
    UniProt: Q8IZP7

  • Chr Location
    13q32.1; chr13:96090107-96839562 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
  • All Mutations and Alleles
    6
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    1
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Hs6st3
  • Incidental Mutations
    Mutagenetix , APF
  • Find Mice (IMSR)
    24 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    903
  • Tissues
    147
  • cDNA Data
    8
  • Literature Summary
    13
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000053465 Ensembl Gene Model | MGI Sequence Detail 731475 C57BL/6J ±  kb
transcript ENSMUST00000065904 Ensembl | MGI Sequence Detail 1708 Not Applicable  
polypeptide ENSMUSP00000070394 Ensembl | MGI Sequence Detail 470 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000008767 heparan-sulfate 6-O-sulfotransferase 3
    (term hierarchy)
  • EC
    2.8.2.-
  • InterPro Domains
    IPR010635 Heparan sulphate 6-sulfotransferase/Protein-tyrosine sulfotransferase
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR005331 Sulfotransferase
  • GlyGen
    Q9QYK4 6 sites, 3 N-linked glycans (3 sites)
Molecular
Reagents
less
  • All nucleic 13
    cDNA 8
    Primer pair 5

    Microarray probesets 2
References
more
  • Summaries
    All 39
    Developmental Gene Expression 13
    Gene Ontology 5
    Phenotypes 7
  • Earliest
    J:60682 Habuchi H, et al., The occurrence of three isoforms of heparan sulfate 6-O-sulfotransferase having different specificities for hexuronic acid adjacent to the targeted N-sulfoglucosamine. J Biol Chem. 2000 Jan 28;275(4):2859-68
  • Latest
    J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory