Tmeff2 MGI Mouse Gene Detail - MGI:1861735 - transmembrane protein with EGF-like and two follistatin-like domains 2

Symbol

Tmeff2
Name

transmembrane protein with EGF-like and two follistatin-like domains 2
Synonyms

4832418D20Rik, 7630402F16Rik

Feature Type

protein coding gene
IDs

MGI:1861735
NCBI Gene: 56363
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr1:50951946-51226429 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 25.95 cM, cytoband C1
Mapping Data

2 experiments

SNPs within 2kb

7383 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1861735	protein coding gene	Chr1:50939806-51226429 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016001	protein coding gene	Chr1:50384269-50685424 (+)
A/J	MGP_AJ_G0015983	protein coding gene	Chr1:48682662-48971953 (+)
AKR/J	MGP_AKRJ_G0015939	protein coding gene	Chr1:49708872-50013088 (+)
BALB/cJ	MGP_BALBcJ_G0015940	protein coding gene	Chr1:48508292-48798547 (+)
C3H/HeJ	MGP_C3HHeJ_G0015772	protein coding gene	Chr1:50105829-50406028 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0016391	protein coding gene	Chr1:52518159-52835644 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014133	protein coding gene	Chr1:42866218-43140265 (-)
CAST/EiJ	MGP_CASTEiJ_G0015353	protein coding gene	Chr1:49564444-49871074 (+)
CBA/J	MGP_CBAJ_G0015743	protein coding gene	Chr1:53902770-54228710 (+)
DBA/2J	MGP_DBA2J_G0015844	protein coding gene	Chr1:47952390-48242299 (+)
FVB/NJ	MGP_FVBNJ_G0015846	protein coding gene	Chr1:47406549-47692868 (+)
LP/J	MGP_LPJ_G0015915	protein coding gene	Chr1:50834264-51142442 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0015866	protein coding gene	Chr1:56945967-57277032 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016439	protein coding gene	Chr1:49830774-50128446 (+)
PWK/PhJ	MGP_PWKPhJ_G0015139	protein coding gene	Chr1:47809809-48110145 (+)
SPRET/EiJ	no annotation
WSB/EiJ	MGP_WSBEiJ_G0015416	protein coding gene	Chr1:49639544-49938482 (+)

Human Ortholog

TMEFF2, transmembrane protein with EGF like and two follistatin like domains 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TMEFF2, transmembrane protein with EGF like and two follistatin like domains 2
Synonyms

CT120.2, HPP1, TENB2, TPEF, TR, TR-2
Links

HGNC:11867

NCBI Gene ID: 23671

neXtProt AC: NX_Q9UIK5

UniProt: Q9UIK5
Chr Location

2q32.3; chr2:191949043-192194933 (-) GRCh38

MGI Vertebrate Homology

Tmeff2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TMEFF2
Gene Tree

Tmeff2

Diseases

2 with human TMEFF2 associations

				Human Disease	Mouse Models
				prostate cancer IDs prostate cancer DOID:10283 DOID:514 ICD10CM:C61 ICD9CM:185 KEGG:05215 MESH:D011471 NCI:C3343 NCI:C7378 OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959 ORDO:1331 UMLS_CUI:C0033578 UMLS_CUI:C0376358
				urinary bladder cancer IDs urinary bladder cancer DOID:11054 DOID:5428 ICD10CM:C67 ICD9CM:188 ICD9CM:188.9 KEGG:05219 MESH:D001749 NCI:C2901 NCI:C9334 OMIM:109800 UMLS_CUI:C0005684 UMLS_CUI:C0005695

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

1
Radiation induced

1
Targeted

5
Genomic Mutations

2 involving Tmeff2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

35 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a reporter allele display slow postnatal weight gain, decreased white adipose tissue amount, and complete lethality at weaning.

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All GO Annotations

7
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

814
Tissues

30
cDNA Data

9
Literature Summary

8

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tmeff2

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All Sequences

43
RefSeq

6
UniProt

2
CCDS

CCDS14939.1

Ensembl

ENSMUSG00000026109 (Evidence)
NCBI Gene

56363

			Length	Strain/Species	Flank
genomic	56363	NCBI Gene Model \| MGI Sequence Detail	274484	C57BL/6J	± kb
transcript	NM_019790	RefSeq \| MGI Sequence Detail	3339	C57BL/6
polypeptide	Q9QYM9	UniProt \| EBI \| MGI Sequence Detail	374	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000016407 tomoregulin-2

(term hierarchy)
InterPro Domains

IPR000742 EGF-like domain

IPR002350 Kazal domain

IPR036058 Kazal domain superfamily
GlyGen

Q9QYM9 2 sites, 1 N-linked glycan (1 site)

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All nucleic 10

cDNA 10

Microarray probesets 5

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MGI:1924914, MGI:2444694

Summaries

All 42

Developmental Gene Expression 8

Gene Ontology 3

Phenotypes 12
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:305429 Kaiser M, et al., Regulation of otocyst patterning by Tbx2 and Tbx3 is required for inner ear morphogenesis in the mouse. Development. 2021 Apr 15;148(8):dev195651

TSS for Tmeff2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr6619	Chr1:50966656-50966665 (+)	14,715 bp
Tssr6620	Chr1:50966670-50966702 (+)	14,740 bp
Tssr79	Chr1:50997847-50997850 (+)	45,903 bp
Tssr6621	Chr1:51122674-51122677 (+)	170,730 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24