Nfu1 MGI Mouse Gene Detail - MGI:1913290 - NFU1 iron-sulfur cluster scaffold

Symbol

Nfu1
Name

NFU1 iron-sulfur cluster scaffold
Synonyms

0610006G17Rik, CGI-33, Hirip5

Feature Type

protein coding gene
IDs

MGI:1913290
NCBI Gene: 56748
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr6:86986218-87005443 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 37.76 cM, cytoband D2
Mapping Data

3 experiments

SNPs within 2kb

765 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1913290	protein coding gene	Chr6:86986040-87005443 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0030985	protein coding gene	Chr6:88345160-88365376 (+)
A/J	MGP_AJ_G0030951	protein coding gene	Chr6:84921889-84944477 (+)
AKR/J	MGP_AKRJ_G0030882	protein coding gene	Chr6:87388963-87410444 (+)
BALB/cJ	MGP_BALBcJ_G0030964	protein coding gene	Chr6:84932537-84955021 (+)
C3H/HeJ	MGP_C3HHeJ_G0030746	protein coding gene	Chr6:97069379-97088647 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0031421	protein coding gene	Chr6:90727274-90748391 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0028605	protein coding gene	Chr6:83104868-83124400 (+)
CAST/EiJ	MGP_CASTEiJ_G0030073	protein coding gene	Chr6:87452492-87473484 (+)
CBA/J	MGP_CBAJ_G0030648	protein coding gene	Chr6:94286715-94306046 (+)
DBA/2J	MGP_DBA2J_G0030804	protein coding gene	Chr6:84237908-84257106 (+)
FVB/NJ	MGP_FVBNJ_G0030757	protein coding gene	Chr6:83419451-83438916 (+)
LP/J	MGP_LPJ_G0030881	protein coding gene	Chr6:88364057-88384364 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0030790	protein coding gene	Chr6:98389441-98411701 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0031448	protein coding gene	Chr6:87223899-87244389 (+)
PWK/PhJ	MGP_PWKPhJ_G0029788	protein coding gene	Chr6:83195431-83214478 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0029616	protein coding gene	Chr6:86055289-86074335 (+)
WSB/EiJ	MGP_WSBEiJ_G0030154	protein coding gene	Chr6:87688825-87709620 (+)

Human Ortholog

NFU1, NFU1 iron-sulfur cluster scaffold

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NFU1, NFU1 iron-sulfur cluster scaffold
Synonyms

CGI-33, HIRIP, HIRIP5, MMDFS, MMDS1, Nfu, NifU, NIFUC, SPG93
Links

HGNC:16287

NCBI Gene ID: 27247

neXtProt AC: NX_Q9UMS0

UniProt: Q9UMS0
Chr Location

2p13.3; chr2:69395750-69439567 (-) GRCh38

MGI Vertebrate Homology

Nfu1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NFU1
Gene Tree

Nfu1

Diseases

1 with human NFU1 associations

				Human Disease	Mouse Models
				multiple mitochondrial dysfunctions syndrome 1 IDs multiple mitochondrial dysfunctions syndrome 1 DOID:0080133 OMIM:605711 ORDO:401869

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

9 phenotype references

All Mutations and Alleles

5
Gene trapped

2
Spontaneous

1
Targeted

2
Genomic Mutations

1 involving Nfu1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

20 strains or lines available

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All GO Annotations

15
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

760
Tissues

20
cDNA Data

79
Literature Summary

2

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nfu1

ZFIN nfu1

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All Sequences

60
RefSeq

14
UniProt

3
CCDS

CCDS51836.1, CCDS85088.1

Ensembl

ENSMUSG00000029993 (Evidence)
NCBI Gene

56748

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029993	Ensembl Gene Model \| MGI Sequence Detail	19226	C57BL/6J	± kb
transcript	ENSMUST00000120240	Ensembl \| MGI Sequence Detail	1195	Not Applicable
polypeptide	ENSMUSP00000113637	Ensembl \| MGI Sequence Detail	256	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000011185 NFU1 iron-sulfur cluster scaffold, mitochondrial

(term hierarchy)
PDB

1VEH
InterPro Domains

IPR034904 Fe-S cluster assembly domain superfamily

IPR001075 NIF system FeS cluster assembly, NifU, C-terminal

IPR014824 Scaffold protein Nfu/NifU, N-terminal

IPR036498 Scaffold protein Nfu/NifU, N-terminal domain superfamily
GlyGen

Q9QZ23 1 site, 1 O-linked glycan (1 site)

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All nucleic 81

cDNA 80

Primer pair 1

Microarray probesets 5

Summaries

All 39

Developmental Gene Expression 2

Gene Ontology 7

Phenotypes 9
Earliest

J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
Latest

J:330636 Iwata S, et al., An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain. G3 (Bethesda). 2021;11(8)

TSS for Nfu1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr57522	Chr6:86986212-86986235 (+)	6 bp
Tssr57523	Chr6:86986854-86986875 (+)	647 bp
Tssr57524	Chr6:86999978-86999991 (+)	13,767 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24