Plxnc1 MGI Mouse Gene Detail - MGI:1890127

Symbol

Plxnc1
Name

plexin C1
Synonyms

2510048K12Rik, CD232, vespr

Feature Type

protein coding gene
IDs

MGI:1890127
NCBI Gene: 54712
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr10:94626728-94780697 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 49.09 cM, cytoband C3
Mapping Data

3 experiments

SNPs within 2kb

3831 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1890127	protein coding gene	Chr10:94626728-94780875 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017666	protein coding gene	Chr10:96299023-96461885 (-)
A/J	MGP_AJ_G0017645	protein coding gene	Chr10:92913975-93069643 (-)
AKR/J	MGP_AKRJ_G0017603	protein coding gene	Chr10:95570039-95728737 (-)
BALB/cJ	MGP_BALBcJ_G0017608	protein coding gene	Chr10:93186864-93342532 (-)
C3H/HeJ	MGP_C3HHeJ_G0017431	protein coding gene	Chr10:95568334-95729898 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018065	protein coding gene	Chr10:99488893-99648416 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015746	protein coding gene	Chr10:88481128-88638693 (-)
CAST/EiJ	MGP_CASTEiJ_G0016996	protein coding gene	Chr10:95590701-95743969 (-)
CBA/J	MGP_CBAJ_G0017400	protein coding gene	Chr10:103599589-103773010 (-)
DBA/2J	MGP_DBA2J_G0017506	protein coding gene	Chr10:92015491-92171937 (-)
FVB/NJ	MGP_FVBNJ_G0017498	protein coding gene	Chr10:91243865-91399624 (-)
LP/J	MGP_LPJ_G0017580	protein coding gene	Chr10:96913525-97080045 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017529	protein coding gene	Chr10:104800665-104963529 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018102	protein coding gene	Chr10:95478058-95636430 (-)
PWK/PhJ	MGP_PWKPhJ_G0016777	protein coding gene	Chr10:92104583-92261808 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016565	protein coding gene	Chr10:94275717-94440056 (-)
WSB/EiJ	MGP_WSBEiJ_G0017055	protein coding gene	Chr10:95445466-95602723 (-)

Human Ortholog

PLXNC1, plexin C1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PLXNC1, plexin C1
Synonyms

CD232, PLXN-C1, VESPR
Links

HGNC:9106

NCBI Gene ID: 10154

neXtProt AC: NX_O60486

UniProt: O60486
Chr Location

12q22; chr12:94148577-94307675 (+) GRCh38

MGI Vertebrate Homology

Plxnc1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: PLXNC1
Gene Tree

Plxnc1

less

Phenotype Summary

15 phenotypes from 2 alleles in 4 genetic backgrounds
44 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

1
Spontaneous

1
Targeted

4
Transposon induced

1
Genomic Mutations

3 involving Plxnc1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

80 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit abnormal neuron morphology and migration.

less

All GO Annotations

16
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1008
Tissues

208
cDNA Data

83
Literature Summary

28

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase plxnc1

less

All Sequences

46
RefSeq

4
UniProt

4
CCDS

CCDS48676.1

Ensembl

ENSMUSG00000074785 (Evidence)
NCBI Gene

54712

			Length	Strain/Species	Flank
genomic	ENSMUSG00000074785	Ensembl Gene Model \| MGI Sequence Detail	153970	C57BL/6J	± kb
transcript	ENSMUST00000099337	Ensembl \| MGI Sequence Detail	7302	Not Applicable
polypeptide	ENSMUSP00000096939	Ensembl \| MGI Sequence Detail	1574	Not Applicable

less

UniProt

4 Sequences
Protein Ontology

PR:000001910 plexin-C1

(term hierarchy)
InterPro Domains

IPR013783 Immunoglobulin-like fold

IPR002909 IPT domain

IPR041853 Plexin-C1, Sema domain

IPR013548 Plexin, cytoplasmic RasGAP domain

IPR046800 Plexin, cytoplasmic RhoGTPase-binding domain

IPR031148 Plexin family

IPR002165 Plexin repeat

IPR016201 PSI domain

IPR008936 Rho GTPase activation protein

IPR001627 Sema domain

IPR036352 Sema domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily
GlyGen

Q9QZC2 19 sites, 22 N-linked glycans (16 sites), 1 O-linked glycan (1 site)

less

All nucleic 89

cDNA 85

Primer pair 2

Other 2

Microarray probesets 7

less

MGI:1921458, MGI:2143873

Summaries

All 97

Developmental Gene Expression 28

Gene Ontology 4

Phenotypes 44
Earliest

J:220665 Bradford GE, Selection for litter size in mice in the presence and absence of gonadotropin treatment. Genetics. 1968 Feb;58(2):283-95
Latest

J:353444 Bessa P, et al., Semaphorin heterodimerization in cis regulates membrane targeting and neocortical wiring. Nat Commun. 2024 Aug 16;15(1):7059

TSS for Plxnc1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr99009	Chr10:94780824-94780854 (-)	-142 bp
Tssr99008	Chr10:94780785-94780801 (-)	-96 bp
Tssr99007	Chr10:94780727-94780753 (-)	-43 bp
Tssr99006	Chr10:94780697-94780724 (-)	-14 bp
Tssr99005	Chr10:94780652-94780693 (-)	24 bp
Tssr99004	Chr10:94780397-94780408 (-)	294 bp
Tssr99003	Chr10:94780032-94780097 (-)	632 bp
Tssr99002	Chr10:94779735-94779749 (-)	955 bp
Tssr99001	Chr10:94779650-94779721 (-)	1,011 bp
Tssr99000	Chr10:94691418-94691435 (-)	89,270 bp
Tssr98999	Chr10:94691343-94691364 (-)	89,343 bp
Tssr98998	Chr10:94665373-94665394 (-)	115,313 bp
Tssr98997	Chr10:94665317-94665345 (-)	115,366 bp
Tssr98996	Chr10:94627907-94627911 (-)	152,788 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24