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Myo15a Gene Detail
Summary
  • Symbol
    Myo15a
  • Name
    myosin XVA
  • Synonyms
    Myo15
  • Feature Type
    protein coding gene
  • IDs
    MGI:1261811
    NCBI Gene: 17910
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:60360165-60419195 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 37.81 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1362 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1261811
 protein coding gene Chr11:60360165-60419195 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018419
 protein coding gene Chr11:60348452-60413680 (+)
A/J MGP_AJ_G0018388
 protein coding gene Chr11:58061033-58120035 (+)
AKR/J MGP_AKRJ_G0018358
 protein coding gene Chr11:60000089-60063710 (+)
BALB/cJ MGP_BALBcJ_G0018359
 protein coding gene Chr11:58403012-58474523 (+)
C3H/HeJ MGP_C3HHeJ_G0018172
 protein coding gene Chr11:59879237-59937825 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018811
 protein coding gene Chr11:62257544-62323073 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016457
 protein coding gene Chr11:55294841-55355128 (+)
CAST/EiJ MGP_CASTEiJ_G0017729
 protein coding gene Chr11:60017396-60077521 (+)
CBA/J MGP_CBAJ_G0018146
 protein coding gene Chr11:64993631-65060809 (+)
DBA/2J MGP_DBA2J_G0018255
 protein coding gene Chr11:57714450-57773329 (+)
FVB/NJ MGP_FVBNJ_G0018246
 protein coding gene Chr11:57383623-57453727 (+)
LP/J MGP_LPJ_G0018328
 protein coding gene Chr11:60956058-61018343 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018270
 protein coding gene Chr11:66044005-66102591 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018852
 protein coding gene Chr11:60030396-60089693 (+)
PWK/PhJ MGP_PWKPhJ_G0017500
 protein coding gene Chr11:58323947-58383367 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017292
 protein coding gene Chr11:59827856-59887348 (+)
WSB/EiJ MGP_WSBEiJ_G0017780
 protein coding gene Chr11:59709495-59770901 (+)



Homology
more
  • Human Ortholog
    MYO15A, myosin XVA
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MYO15A, myosin XVA
  • Synonyms
    DFNB3, MYO15
  • Links
    NCBI Gene ID: 51168
    neXtProt AC: NX_Q9UKN7
    UniProt: Q9UKN7

  • Chr Location
    17p11.2; chr17:18108756-18179802 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Myo15a mouse models; 2 with human MYO15A associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    5 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 9 alleles in 11 genetic backgrounds
    35 phenotypes from multigenic genotypes
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene result in profound deafness and neurological behavior.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    766
  • Tissues
    27
  • cDNA Data
    12
  • Literature Summary
    20
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17910 NCBI Gene Model | MGI Sequence Detail 59031 C57BL/6J ±  kb
    transcript NM_010862 RefSeq | MGI Sequence Detail 11769 Not Specified  
    polypeptide Q9QZZ4 UniProt | EBI | MGI Sequence Detail 3511 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 2
      cDNA 15
      Primer pair 3
      Other 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-14392, MGD-MRK-14394, MGI:7282040, MGI:98292
    References
    more
    • Summaries
      All 129
      Developmental Gene Expression 20
      Diseases 5
      Gene Ontology 12
      Phenotypes 77
    • Earliest
      J:15021 Dobrovolskaia-Zavasdkaia N, L'irradiation des testicules et l'heredite chez la souris. Arch Biol (Liege). 1928;38:457-501
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory