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Naip5 Gene Detail
Summary
  • Symbol
    Naip5
  • Name
    NLR family, apoptosis inhibitory protein 5
  • Synonyms
    Birc1e, Lgn1, Naip-rs3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298220
    NCBI Gene: 17951
  • Member of
    Naipc cluster
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:100348247-100382831 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 53.05 cM, cytoband D1-D3
  • Mapping Data
    24 experiments
Strain
Comparison
more
  • SNPs within 2kb
    39 from dbSNP Build 142
  • Strain Annotations
    6
  • PCR
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298220
 protein coding gene Chr13:100348243-100387437 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020883
 protein coding gene Chr13:102062977-102105871 (-)
A/J no annotation
AKR/J no annotation
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0018839
 protein coding gene Chr13:93829568-94216792 (-)
CAST/EiJ MGP_CASTEiJ_G0020144
 protein coding gene Chr13:100292653-100305372 (-)
CBA/J no annotation
DBA/2J no annotation
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0020721
 protein coding gene Chr13:109594260-109628373 (-)
NZO/HlLtJ no annotation
PWK/PhJ MGP_PWKPhJ_G0019897
 protein coding gene Chr13:96718840-96743824 (-)
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    NAIP, NLR family apoptosis inhibitory protein
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NAIP, NLR family apoptosis inhibitory protein
  • Synonyms
    BIRC1, NLRB1, psiNAIP
  • Links
    NCBI Gene ID: 4671
    neXtProt AC: NX_Q13075
    UniProt: Q13075

  • Chr Location
    5q13.2; chr5:70968166-71025339 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 4 alleles in 4 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
This locus controls resistance to Legionella pneumophila, the organism responsible for Legionnaire's disease. Cultured peritoneal macrophages from A/J mice are susceptible, supporting bacterial proliferation; other strains, e.g., C57BL/6 are resistant.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    33
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    795
  • Tissues
    66
  • cDNA Data
    7
  • Literature Summary
    4
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000071203 Ensembl Gene Model | MGI Sequence Detail 34585 C57BL/6J ±  kb
transcript ENSMUST00000049789 Ensembl | MGI Sequence Detail 5204 Not Applicable  
polypeptide ENSMUSP00000058611 Ensembl | MGI Sequence Detail 1403 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 38
    Genomic 28
    cDNA 7
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16416, MGD-MRK-38482, MGI:109437, MGI:99631
References
more
  • Summaries
    All 87
    Developmental Gene Expression 4
    Gene Ontology 16
    Phenotypes 34
  • Earliest
    J:20633 Yoshida S, et al., Genetic control of natural resistance in mouse macrophages regulating intracellular Legionella pneumophila multiplication in vitro. Infect Immun. 1991 Jan;59(1):428-32
  • Latest
    J:348226 Amaral MP, et al., NAIP/NLRC4 inflammasome participates in macrophage responses to Trypanosoma cruzi by a mechanism that relies on cathepsin-dependent caspase-1 cleavage. Front Immunol. 2023;14:1282856
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory