Lamc3 MGI Mouse Gene Detail - MGI:1344394

Symbol

Lamc3
Name

laminin gamma 3

Feature Type

protein coding gene
IDs

MGI:1344394
NCBI Gene: 23928
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr2:31777303-31836551 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 21.93 cM, cytoband B
Mapping Data

3 experiments

SNPs within 2kb

1529 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1344394	protein coding gene	Chr2:31777293-31839095 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0025592	protein coding gene	Chr2:30276345-30340966 (+)
A/J	MGP_AJ_G0025570	protein coding gene	Chr2:29019493-29082775 (+)
AKR/J	MGP_AKRJ_G0025539	protein coding gene	Chr2:30015798-30080084 (+)
BALB/cJ	MGP_BALBcJ_G0025566	protein coding gene	Chr2:29143808-29206243 (+)
C3H/HeJ	MGP_C3HHeJ_G0025327	protein coding gene	Chr2:29930689-30001478 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026011	protein coding gene	Chr2:31225682-31291124 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023419	protein coding gene	Chr2:27760115-27820815 (+)
CAST/EiJ	MGP_CASTEiJ_G0024789	protein coding gene	Chr2:29877043-29943051 (+)
CBA/J	MGP_CBAJ_G0025304	protein coding gene	Chr2:32355238-32442910 (+)
DBA/2J	MGP_DBA2J_G0025437	protein coding gene	Chr2:28794139-28852407 (+)
FVB/NJ	MGP_FVBNJ_G0025400	protein coding gene	Chr2:28644219-28704886 (+)
LP/J	MGP_LPJ_G0025523	protein coding gene	Chr2:30150888-30218277 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025430	protein coding gene	Chr2:32084147-32149471 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026069	protein coding gene	Chr2:29932214-29997119 (+)
PWK/PhJ	MGP_PWKPhJ_G0024536	protein coding gene	Chr2:28682671-28744134 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024336	protein coding gene	Chr2:30071493-30138009 (+)
WSB/EiJ	MGP_WSBEiJ_G0024857	protein coding gene	Chr2:30106852-30172427 (+)

Human Ortholog

LAMC3, laminin subunit gamma 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

LAMC3, laminin subunit gamma 3
Synonyms

OCCM
Links

HGNC:6494

NCBI Gene ID: 10319

neXtProt AC: NX_Q9Y6N6

UniProt: Q9Y6N6
Chr Location

9q34.12; chr9:131009174-131094473 (+) GRCh38

MGI Vertebrate Homology

Lamc3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: LAMC3
Gene Tree

Lamc3

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
6 phenotypes from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

6
Endonuclease-mediated

2
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

59 strains or lines available

Mice homozygous for a reporter allele exhibit abnormal amacrine cell morphology.

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All GO Annotations

10
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

928
Tissues

123
cDNA Data

30
Literature Summary

21

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

ZFIN lamc3

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All Sequences

42
RefSeq

2
UniProt

3
CCDS

CCDS15903.1

Ensembl

ENSMUSG00000026840 (Evidence)
NCBI Gene

23928

			Length	Strain/Species	Flank
genomic	ENSMUSG00000026840	Ensembl Gene Model \| MGI Sequence Detail	59249	C57BL/6J	± kb
transcript	ENSMUST00000028187	Ensembl \| MGI Sequence Detail	5871	Not Applicable
polypeptide	ENSMUSP00000028187	Ensembl \| MGI Sequence Detail	1581	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000009660 laminin subunit gamma-3

(term hierarchy)
InterPro Domains

IPR000742 EGF-like domain

IPR000034 Laminin IV

IPR050440 Laminin/Netrin Extracellular Matrix

IPR008211 Laminin, N-terminal

IPR002049 Laminin-type EGF domain
GlyGen

Q9R0B6 10 sites, 6 N-linked glycans (8 sites)

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All nucleic 37

Genomic 1

cDNA 31

Primer pair 4

Other 1

Microarray probesets 4

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MGI:2139003, MGI:2139333

Summaries

All 63

Developmental Gene Expression 21

Gene Ontology 4

Phenotypes 14
Earliest

J:54919 Iivanainen A, et al., Molecular cloning and tissue-specific expression of a novel murine laminin gamma3 chain. J Biol Chem. 1999 May 14;274(20):14107-11
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Lamc3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr17218	Chr2:31777274-31777322 (+)	-5 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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