Emcn MGI Mouse Gene Detail - MGI:1891716

Symbol

Emcn
Name

endomucin
Synonyms

0610012K22Rik

Feature Type

protein coding gene
IDs

MGI:1891716
NCBI Gene: 59308
Alliance

gene page
Transcription Start Sites

6 TSS

Sequence Map

Chr3:137046824-137136830 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 63.65 cM
Mapping Data

2 experiments

SNPs within 2kb

2608 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1891716	protein coding gene	Chr3:137046824-137137946 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027914	protein coding gene	Chr3:140346099-140438768 (+)
A/J	MGP_AJ_G0027871	protein coding gene	Chr3:135421892-135507845 (+)
AKR/J	MGP_AKRJ_G0027837	protein coding gene	Chr3:139006481-139098209 (+)
BALB/cJ	MGP_BALBcJ_G0027884	protein coding gene	Chr3:135235641-135330468 (+)
C3H/HeJ	MGP_C3HHeJ_G0027613	protein coding gene	Chr3:139319465-139411948 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028327	protein coding gene	Chr3:145212771-145311852 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025665	protein coding gene	Chr3:130537921-130623578 (+)
CAST/EiJ	MGP_CASTEiJ_G0027069	protein coding gene	Chr3:139091519-139183185 (+)
CBA/J	MGP_CBAJ_G0027590	protein coding gene	Chr3:150145028-150263392 (+)
DBA/2J	MGP_DBA2J_G0027729	protein coding gene	Chr3:134524593-134630653 (+)
FVB/NJ	MGP_FVBNJ_G0027696	protein coding gene	Chr3:131991123-132074986 (+)
LP/J	MGP_LPJ_G0027839	protein coding gene	Chr3:141760712-141853885 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027728	protein coding gene	Chr3:158278406-158372773 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028385	protein coding gene	Chr3:138527104-138624919 (+)
PWK/PhJ	MGP_PWKPhJ_G0026793	protein coding gene	Chr3:134288297-134377388 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026620	protein coding gene	Chr3:136617575-136712856 (+)
WSB/EiJ	MGP_WSBEiJ_G0027149	protein coding gene	Chr3:139346094-139443694 (+)

Human Ortholog

EMCN, endomucin

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EMCN, endomucin
Synonyms

EMCN2, MUC14
Links

HGNC:16041

NCBI Gene ID: 51705

neXtProt AC: NX_Q9ULC0

UniProt: Q9ULC0
Chr Location

4q24; chr4:100395341-100880126 (-) GRCh38

MGI Vertebrate Homology

Emcn stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: EMCN
Gene Tree

Emcn

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References

1 with disease annotations

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Phenotype Summary

7 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

6
Radiation induced

1
Genomic Mutations

2 involving Emcn
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

29 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

8
GO References

4

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

986
Tissues

116
cDNA Data

52
Literature Summary

277

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

47
RefSeq

6
UniProt

3
CCDS

CCDS17861.1, CCDS51075.1

Ensembl

ENSMUSG00000054690 (Evidence)
NCBI Gene

59308

			Length	Strain/Species	Flank
genomic	59308	NCBI Gene Model \| MGI Sequence Detail	90007	C57BL/6J	± kb
transcript	NM_001163522	RefSeq \| MGI Sequence Detail	1476	C57BL/6
polypeptide	Q9R0H2	UniProt \| EBI \| MGI Sequence Detail	261	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000007049 endomucin

(term hierarchy)
InterPro Domains

IPR010740 Endomucin
GlyGen

Q9R0H2 5 sites

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All nucleic 58

cDNA 52

Primer pair 4

Other 2

Microarray probesets 5

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MGI:1915613, MGI:2139669

Summaries

All 317

Developmental Gene Expression 277

Diseases 1

Gene Ontology 4

Phenotypes 11
Earliest

J:62172 Morgan SM, et al., Biochemical characterization and molecular cloning of a novel endothelial-specific sialomucin. Blood. 1999 Jan 1;93(1):165-75
Latest

J:357405 Brookins E, et al., Non-endothelial expression of endomucin in the mouse and human choroid. Exp Eye Res. 2024 Aug 15;247:110054

TSS for Emcn:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr31897	Chr3:137046793-137046807 (+)	-24 bp
Tssr31898	Chr3:137046837-137046856 (+)	23 bp
Tssr31899	Chr3:137046864-137046907 (+)	62 bp
Tssr31900	Chr3:137046908-137046915 (+)	88 bp
Tssr31901	Chr3:137046940-137046951 (+)	122 bp
Tssr31902	Chr3:137046973-137046984 (+)	155 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24