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Celsr2 Gene Detail
Summary
  • Symbol
    Celsr2
  • Name
    cadherin, EGF LAG seven-pass G-type receptor 2
  • Synonyms
    Adgrc2, EGFL2, flamingo, mfmi1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1858235
    NCBI Gene: 53883
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:108298167-108323383 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 47.02 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    522 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1858235
 protein coding gene Chr3:108298164-108323416 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027776
 protein coding gene Chr3:109940519-109965222 (-)
A/J MGP_AJ_G0027736
 protein coding gene Chr3:106453871-106478572 (-)
AKR/J MGP_AKRJ_G0027701
 protein coding gene Chr3:109045087-109069788 (-)
BALB/cJ MGP_BALBcJ_G0027748
 protein coding gene Chr3:106152819-106177521 (-)
C3H/HeJ MGP_C3HHeJ_G0027478
 protein coding gene Chr3:109397300-109422001 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028192
 protein coding gene Chr3:114046088-114070760 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025530
 protein coding gene Chr3:102598915-102623652 (-)
CAST/EiJ MGP_CASTEiJ_G0026934
 protein coding gene Chr3:108778703-108803527 (-)
CBA/J MGP_CBAJ_G0027453
 protein coding gene Chr3:117934430-117960250 (-)
DBA/2J MGP_DBA2J_G0027595
 protein coding gene Chr3:105634762-105659463 (-)
FVB/NJ MGP_FVBNJ_G0027563
 protein coding gene Chr3:103519433-103544134 (-)
LP/J MGP_LPJ_G0027702
 protein coding gene Chr3:111358548-111384348 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027593
 protein coding gene Chr3:123979342-124004043 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028247
 protein coding gene Chr3:108643748-108668568 (-)
PWK/PhJ MGP_PWKPhJ_G0026660
 protein coding gene Chr3:105384440-105409573 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026480
 protein coding gene Chr3:106785470-106810164 (-)
WSB/EiJ MGP_WSBEiJ_G0027014
 protein coding gene Chr3:109181519-109206223 (-)



Homology
more
  • Human Ortholog
    CELSR2, cadherin EGF LAG seven-pass G-type receptor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CELSR2, cadherin EGF LAG seven-pass G-type receptor 2
  • Synonyms
    ADGRC2, CDHF10, EGFL2, Flamingo1, MEGF3
  • Links
    NCBI Gene ID: 1952
    neXtProt AC: NX_Q9HCU4
    UniProt: Q9HCU4

  • Chr Location
    1p13.3; chr1:109249539-109275751 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Celsr2 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this allele have mild to moderately dilated lateral ventricles in the brain but are otherwise normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    969
  • Tissues
    177
  • cDNA Data
    99
  • Literature Summary
    27
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000068740 Ensembl Gene Model | MGI Sequence Detail 25217 C57BL/6J ±  kb
    transcript ENSMUST00000090558 Ensembl | MGI Sequence Detail 11113 Not Applicable  
    polypeptide ENSMUSP00000088046 Ensembl | MGI Sequence Detail 2919 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 104
      cDNA 99
      Primer pair 3
      Other 2

      Microarray probesets 5
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 27
      Diseases 2
      Gene Ontology 12
      Phenotypes 19
    • Earliest
      J:64424 Usui T, et al., Flamingo, a seven-pass transmembrane cadherin, regulates planar cell polarity under the control of Frizzled. Cell. 1999 Sep 3;98(5):585-95
    • Latest
      J:353578 Paramore SV, et al., Mesenchymal Vangl1 and Vangl2 facilitate airway elongation and widening independently of the planar cell polarity complex. Development. 2024 Aug 15;151(16):dev202692
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory