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Sytl4 Gene Detail
Summary
  • Symbol
    Sytl4
  • Name
    synaptotagmin-like 4
  • Synonyms
    granuphilin-a, granuphilin-b, Slp4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1351606
    NCBI Gene: 27359
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:132837134-132882561 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 55.47 cM, cytoband E3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    849 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1351606
 protein coding gene ChrX:132837134-132882569 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036059
 protein coding gene ChrX:131079241-131124668 (-)
A/J MGP_AJ_G0036041
 protein coding gene ChrX:130509616-130553531 (-)
AKR/J MGP_AKRJ_G0035960
 protein coding gene ChrX:134678851-134724197 (-)
BALB/cJ MGP_BALBcJ_G0036032
 protein coding gene ChrX:128956853-129002977 (-)
C3H/HeJ MGP_C3HHeJ_G0035736
 protein coding gene ChrX:131163960-131207952 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036554
 protein coding gene ChrX:134946628-134990839 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033382
 protein coding gene ChrX:122714253-122760895 (-)
CAST/EiJ MGP_CASTEiJ_G0035023
 protein coding gene ChrX:112040826-112087529 (-)
CBA/J MGP_CBAJ_G0035713
 protein coding gene ChrX:138984383-139028310 (-)
DBA/2J MGP_DBA2J_G0035866
 protein coding gene ChrX:129851330-129895218 (-)
FVB/NJ MGP_FVBNJ_G0035808
 protein coding gene ChrX:129160125-129207464 (-)
LP/J MGP_LPJ_G0035959
 protein coding gene ChrX:131960494-132005589 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035836
 protein coding gene ChrX:146380200-146432285 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036583
 protein coding gene ChrX:130512772-130561824 (-)
PWK/PhJ MGP_PWKPhJ_G0034715
 protein coding gene ChrX:108998409-109043596 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034547
 protein coding gene ChrX:112666808-112713560 (-)
WSB/EiJ MGP_WSBEiJ_G0035160
 protein coding gene ChrX:128893591-128940232 (-)



Homology
more
  • Human Ortholog
    SYTL4, synaptotagmin like 4
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SYTL4, synaptotagmin like 4
  • Synonyms
    SLP4
  • Links
    NCBI Gene ID: 94121
    neXtProt AC: NX_Q96C24
    UniProt: Q96C24

  • Chr Location
    Xq22.1; chrX:100671783-100732123 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    2 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Targeted inactivation of this gene leads to reduced body weight, enhanced glucose tolerance, defective granule docking at the plasma membrane in pancreatic beta cells and corticotrophs, and a significant increase in evoked insulin and adrenocorticotropinsecretion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    740
  • Tissues
    13
  • cDNA Data
    18
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031255 Ensembl Gene Model | MGI Sequence Detail 45428 C57BL/6J ±  kb
    transcript ENSMUST00000033608 Ensembl | MGI Sequence Detail 3753 Not Applicable  
    polypeptide ENSMUSP00000033608 Ensembl | MGI Sequence Detail 673 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 18
      Primer pair 1

      Microarray probesets 5
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 5
      Gene Ontology 13
      Phenotypes 12
    • Earliest
      J:30814 Neophytou PI, et al., A subtractive cloning approach to the identification of mRNAs specifically expressed in pancreatic beta-cells. Diabetes. 1996 Feb;45(2):127-33
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory