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Tmed2 Gene Detail
Summary
  • Symbol
    Tmed2
  • Name
    transmembrane p24 trafficking protein 2
  • Synonyms
    1110032D12Rik, 1810020N21Rik, p24beta1, Sid394
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929269
    NCBI Gene: 56334
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:124678835-124688566 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 63.65 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    258 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929269
 protein coding gene Chr5:124678758-124688569 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030099
 protein coding gene Chr5:128371430-128381047 (+)
A/J MGP_AJ_G0030064
 protein coding gene Chr5:123015142-123024717 (+)
AKR/J MGP_AKRJ_G0030000
 protein coding gene Chr5:126985813-126996141 (+)
BALB/cJ MGP_BALBcJ_G0030075
 protein coding gene Chr5:124354498-124362873 (+)
C3H/HeJ MGP_C3HHeJ_G0029792
 protein coding gene Chr5:127595866-127606377 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030528
 protein coding gene Chr5:133356299-133366106 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027754
 protein coding gene Chr5:117552052-117561936 (+)
CAST/EiJ MGP_CASTEiJ_G0029201
 protein coding gene Chr5:126710812-126722571 (+)
CBA/J MGP_CBAJ_G0029762
 protein coding gene Chr5:138571274-138582026 (+)
DBA/2J MGP_DBA2J_G0029912
 protein coding gene Chr5:123036269-123045918 (+)
FVB/NJ MGP_FVBNJ_G0029868
 protein coding gene Chr5:122083911-122093545 (+)
LP/J MGP_LPJ_G0030001
 protein coding gene Chr5:128906409-128915835 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029899
 protein coding gene Chr5:142141569-142152569 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030569
 protein coding gene Chr5:126605818-126615276 (+)
PWK/PhJ MGP_PWKPhJ_G0028915
 protein coding gene Chr5:121861811-121871848 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028752
 protein coding gene Chr5:124231816-124241988 (+)
WSB/EiJ MGP_WSBEiJ_G0029275
 protein coding gene Chr5:127288808-127301561 (+)



Homology
more
  • Human Ortholog
    TMED2, transmembrane p24 trafficking protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TMED2, transmembrane p24 trafficking protein 2
  • Synonyms
    p24, P24A, p24b1, p24beta1, RNP24
  • Links
    NCBI Gene ID: 10959
    neXtProt AC: NX_Q15363
    UniProt: Q15363

  • Chr Location
    12q24.31; chr12:123584533-123598582 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    18 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit embryonic lethality, embryonic growth retardation, caudal body truncation, and abnormal heart development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    68
  • GO References
    12
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    815
  • Tissues
    74
  • cDNA Data
    14
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56334 NCBI Gene Model | MGI Sequence Detail 9732 C57BL/6J ±  kb
    transcript NM_001403253 RefSeq | MGI Sequence Detail 2015 C57BL/6  
    polypeptide Q9R0Q3 UniProt | EBI | MGI Sequence Detail 201 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 14
      Primer pair 4
      Other 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGI:1916364, MGI:1923572
    References
    more
    • Summaries
      All 44
      Developmental Gene Expression 5
      Gene Ontology 12
      Phenotypes 14
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:335878 Montanes-Agudo P, et al., The RNA-binding protein QKI governs a muscle-specific alternative splicing program that shapes the contractile function of cardiomyocytes. Cardiovasc Res. 2023 May 22;119(5):1161-1174
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory