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Meltf Gene Detail
Summary
  • Symbol
    Meltf
  • Name
    melanotransferrin
  • Synonyms
    CD228, melanotransferrin, Mfi2, MTf
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353421
    NCBI Gene: 30060
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:31697628-31717838 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 22.40 cM, cytoband B3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    619 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353421
 protein coding gene Chr16:31697449-31717838 (+)
129S1/SvImJ MGP_129S1SvImJ_G0022722
 protein coding gene Chr16:29874382-29895915 (+)
A/J MGP_AJ_G0022687
 protein coding gene Chr16:28507286-28527495 (+)
AKR/J MGP_AKRJ_G0022660
 protein coding gene Chr16:29543203-29563416 (+)
BALB/cJ MGP_BALBcJ_G0022689
 protein coding gene Chr16:28659261-28679466 (+)
C3H/HeJ MGP_C3HHeJ_G0022454
 protein coding gene Chr16:29665232-29685560 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023138
 protein coding gene Chr16:30524017-30544227 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020656
 protein coding gene Chr16:28875297-28895305 (+)
CAST/EiJ MGP_CASTEiJ_G0021982
 protein coding gene Chr16:29783159-29805274 (+)
CBA/J MGP_CBAJ_G0022424
 protein coding gene Chr16:31779016-31799384 (+)
DBA/2J MGP_DBA2J_G0022557
 protein coding gene Chr16:28354218-28374536 (+)
FVB/NJ MGP_FVBNJ_G0022532
 protein coding gene Chr16:28337256-28357470 (+)
LP/J MGP_LPJ_G0022624
 protein coding gene Chr16:29670602-29690925 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022551
 protein coding gene Chr16:31246908-31267116 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023150
 protein coding gene Chr16:29514573-29534784 (+)
PWK/PhJ MGP_PWKPhJ_G0021721
 protein coding gene Chr16:28665730-28686082 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021552
 protein coding gene Chr16:29298840-29319000 (+)
WSB/EiJ MGP_WSBEiJ_G0022026
 protein coding gene Chr16:29456613-29476837 (+)



Homology
more
  • Human Ortholog
    MELTF, melanotransferrin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MELTF, melanotransferrin
  • Synonyms
    CD228, MAP97, MFI2, MTf, MTF1
  • Links
    NCBI Gene ID: 4241
    neXtProt AC: NX_P08582
    UniProt: P08582

  • Chr Location
    3q29; chr3:196980590-197029835 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Mice homozygous for a knock-out allele are viable and fertile, exhibit no physical defects, and develop normally with no detectable alterations in iron metabolism.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    764
  • Tissues
    24
  • cDNA Data
    37
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022780 Ensembl Gene Model | MGI Sequence Detail 20211 C57BL/6J ±  kb
transcript ENSMUST00000023464 Ensembl | MGI Sequence Detail 4133 Not Applicable  
polypeptide ENSMUSP00000023464 Ensembl | MGI Sequence Detail 738 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 38
    cDNA 37
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 39
    Developmental Gene Expression 4
    Gene Ontology 7
    Phenotypes 14
  • Earliest
    J:58252 Nakamasu K, et al., Membrane-bound transferrin-like protein (MTf): structure, evolution and selective expression during chondrogenic differentiation of mouse embryonic cells. Biochim Biophys Acta. 1999 Oct 28;1447(2-3):258-64
  • Latest
    J:351035 Tan Z, et al., Progenitor-like cells contributing to cellular heterogeneity in the nucleus pulposus are lost in intervertebral disc degeneration. Cell Rep. 2024 Jun 25;43(6):114342
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
10/29/2024
MGI 6.24 		The Jackson Laboratory