Ikbke MGI Mouse Gene Detail - MGI:1929612 - inhibitor of kappaB kinase epsilon

Symbol

Ikbke
Name

inhibitor of kappaB kinase epsilon
Synonyms

IKKepsilon, IKK-i

Feature Type

protein coding gene
IDs

MGI:1929612
NCBI Gene: 56489
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr1:131182337-131207339 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 1, 56.93 cM
Mapping Data

2 experiments

SNPs within 2kb

772 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929612	protein coding gene	Chr1:131182080-131207344 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0016452	protein coding gene	Chr1:134677593-134703243 (-)
A/J	MGP_AJ_G0016435	protein coding gene	Chr1:129703455-129729259 (-)
AKR/J	MGP_AKRJ_G0016400	protein coding gene	Chr1:133515047-133540430 (-)
BALB/cJ	MGP_BALBcJ_G0016395	protein coding gene	Chr1:130031184-130056456 (-)
C3H/HeJ	MGP_C3HHeJ_G0016221	protein coding gene	Chr1:133651629-133678545 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0016856	protein coding gene	Chr1:139684685-139713193 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0014570	protein coding gene	Chr1:122837537-122863880 (-)
CAST/EiJ	MGP_CASTEiJ_G0015801	protein coding gene	Chr1:132652032-132675611 (-)
CBA/J	MGP_CBAJ_G0016193	protein coding gene	Chr1:144489608-144517553 (-)
DBA/2J	MGP_DBA2J_G0016300	protein coding gene	Chr1:128668589-128694453 (-)
FVB/NJ	MGP_FVBNJ_G0016299	protein coding gene	Chr1:127297162-127323342 (-)
LP/J	MGP_LPJ_G0016371	protein coding gene	Chr1:135996500-136021687 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016324	protein coding gene	Chr1:150254119-150282028 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0016892	protein coding gene	Chr1:133281476-133306695 (-)
PWK/PhJ	MGP_PWKPhJ_G0015587	protein coding gene	Chr1:127625133-127650659 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0015374	protein coding gene	Chr1:132208925-132235490 (-)
WSB/EiJ	MGP_WSBEiJ_G0015863	protein coding gene	Chr1:133262357-133288665 (-)

Human Ortholog

IKBKE, inhibitor of nuclear factor kappa B kinase subunit epsilon

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IKBKE, inhibitor of nuclear factor kappa B kinase subunit epsilon
Synonyms

IKK-E, IKKE, IKK-i, IKKI
Links

HGNC:14552

NCBI Gene ID: 9641

neXtProt AC: NX_Q14164

UniProt: Q14164
Chr Location

1q32.1; chr1:206470476-206496889 (+) GRCh38

MGI Vertebrate Homology

Ikbke stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: IKBKE
Gene Tree

Ikbke

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Phenotype Summary

10 phenotypes from 3 alleles in 3 genetic backgrounds
43 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Chemically induced (other)

2
Endonuclease-mediated

2
Radiation induced

1
Targeted

5
Genomic Mutations

3 involving Ikbke
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

55 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice are viable and fertile.

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All GO Annotations

42
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

782
Tissues

24
cDNA Data

33
Literature Summary

3

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ikbke

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All Sequences

67
RefSeq

15
UniProt

6
CCDS

CCDS15269.1

Ensembl

ENSMUSG00000042349 (Evidence)
NCBI Gene

56489

			Length	Strain/Species	Flank
genomic	56489	NCBI Gene Model \| MGI Sequence Detail	25003	C57BL/6J	± kb
transcript	NM_019777	RefSeq \| MGI Sequence Detail	3203	NOD
polypeptide	Q9R0T8	UniProt \| EBI \| MGI Sequence Detail	717	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000001778 inhibitor of nuclear factor kappa-B kinase subunit epsilon

(term hierarchy)
EC

2.7.11.10
InterPro Domains

IPR051180 Inhibitor of nuclear factor kappa-B kinase

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR041309 TANK-binding kinase 1, coiled-coil domain 1

IPR041087 TANK binding kinase 1, ubiquitin-like domain

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All nucleic 34

cDNA 33

Primer pair 1

Microarray probesets 3

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MGI:2138621

Summaries

All 98

Developmental Gene Expression 3

Gene Ontology 10

Phenotypes 43
Earliest

J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
Latest

J:351145 Eren RO, et al., IKKepsilon and TBK1 prevent RIPK1 dependent and independent inflammation. Nat Commun. 2024 Jan 2;15(1):130

TSS for Ikbke:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr13578	Chr1:131207282-131207308 (-)	44 bp
Tssr13577	Chr1:131207253-131207267 (-)	79 bp
Tssr13576	Chr1:131206493-131206505 (-)	840 bp
Tssr13575	Chr1:131204651-131204662 (-)	2,682 bp
Tssr13574	Chr1:131204632-131204643 (-)	2,701 bp
Tssr13573	Chr1:131204614-131204625 (-)	2,719 bp
Tssr13572	Chr1:131204534-131204550 (-)	2,797 bp
Tssr13571	Chr1:131204422-131204457 (-)	2,899 bp
Tssr13570	Chr1:131203014-131203042 (-)	4,311 bp
Tssr13569	Chr1:131201212-131201223 (-)	6,121 bp
Tssr13568	Chr1:131199599-131199615 (-)	7,732 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24