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Dlc1 Gene Detail
Summary
  • Symbol
    Dlc1
  • Name
    deleted in liver cancer 1
  • Synonyms
    A730069N07Rik, Arhgap7, p122-RhoGAP, STARD12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1354949
    NCBI Gene: 50768
  • Alliance
    gene page
  • Transcription Start Sites
    28 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:37034905-37420297 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 23.05 cM, cytoband A4-B2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    11122 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1354949
 protein coding gene Chr8:37034893-37420343 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033545
 protein coding gene Chr8:35241740-35644636 (-)
A/J MGP_AJ_G0033525
 protein coding gene Chr8:33863405-34248744 (-)
AKR/J MGP_AKRJ_G0033449
 protein coding gene Chr8:34899416-35293342 (-)
BALB/cJ MGP_BALBcJ_G0033521
 protein coding gene Chr8:33955191-34346718 (-)
C3H/HeJ MGP_C3HHeJ_G0033233
 protein coding gene Chr8:35251709-35670978 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034037
 protein coding gene Chr8:36541741-36953377 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030986
 protein coding gene Chr8:30769149-31167679 (-)
CAST/EiJ MGP_CASTEiJ_G0032560
 protein coding gene Chr8:34723113-35121571 (-)
CBA/J MGP_CBAJ_G0033211
 protein coding gene Chr8:37992259-38415456 (-)
DBA/2J MGP_DBA2J_G0033364
 protein coding gene Chr8:33768048-34160147 (-)
FVB/NJ MGP_FVBNJ_G0033309
 protein coding gene Chr8:33423638-33812791 (-)
LP/J MGP_LPJ_G0033454
 protein coding gene Chr8:35210324-35609321 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033351
 protein coding gene Chr8:37378297-37806330 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034056
 protein coding gene Chr8:35046066-35452776 (-)
PWK/PhJ MGP_PWKPhJ_G0032270
 protein coding gene Chr8:33330554-33723341 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032102
 protein coding gene Chr8:34276198-34687770 (-)
WSB/EiJ MGP_WSBEiJ_G0032676
 protein coding gene Chr8:35233682-35645881 (-)



Homology
more
  • Human Ortholog
    DLC1, DLC1 Rho GTPase activating protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DLC1, DLC1 Rho GTPase activating protein
  • Synonyms
    ARHGAP7, HP, p122-RhoGAP, STARD12
  • Links
    NCBI Gene ID: 10395
    neXtProt AC: NX_Q96QB1
    UniProt: Q96QB1

  • Chr Location
    8p22; chr8:13083361-13604620 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DLC1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 3 alleles in 2 genetic backgrounds
    2 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants die by E10.5 with variable defects in the neural tube, heart, brain and placenta. Mouse embryonic fibroblasts homozygous for an activated conditional allele exhibti increased sensitivity to Ras-induced transformation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    46
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    827
  • Tissues
    30
  • cDNA Data
    21
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031523 Ensembl Gene Model | MGI Sequence Detail 385393 C57BL/6J ±  kb
    transcript ENSMUST00000163663 Ensembl | MGI Sequence Detail 5113 Not Applicable  
    polypeptide ENSMUSP00000132812 Ensembl | MGI Sequence Detail 1543 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 31
      Genomic 1
      cDNA 21
      Primer pair 7
      Other 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:2442088
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 6
      Gene Ontology 8
      Phenotypes 17
    • Earliest
      J:60865 Yuan BZ, et al., Assignment and cloning of mouse Arhgap7 to chromosome 8A4-B2, a conserved syntenic region of human chromosome 8p22-->p21. Cytogenet Cell Genet. 1999;87(3-4):189-90
    • Latest
      J:352711 Zhao R, et al., Identification and characterization of intermediate states in mammalian neural crest cell epithelial to mesenchymal transition and delamination. Elife. 2024 Jun 14;13
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory