Gda MGI Mouse Gene Detail - MGI:95678

Symbol

Gda
Name

guanine deaminase

Feature Type

protein coding gene
IDs

MGI:95678
NCBI Gene: 14544
Alliance

gene page
Transcription Start Sites

14 TSS

Sequence Map

Chr19:21368671-21450025 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 19, 14.32 cM
Mapping Data

4 experiments

SNPs within 2kb

3018 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95678	protein coding gene	Chr19:21368671-21450809 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0024977	protein coding gene	Chr19:19420955-19504117 (-)
A/J	MGP_AJ_G0024954	protein coding gene	Chr19:18373653-18454772 (-)
AKR/J	MGP_AKRJ_G0024924	protein coding gene	Chr19:19065735-19149847 (-)
BALB/cJ	MGP_BALBcJ_G0024953	protein coding gene	Chr19:18369795-18450632 (-)
C3H/HeJ	MGP_C3HHeJ_G0024711	protein coding gene	Chr19:19020837-19104109 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0025395	protein coding gene	Chr19:20093118-20177179 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0022814	protein coding gene	Chr19:18596597-18678090 (-)
CAST/EiJ	MGP_CASTEiJ_G0024179	protein coding gene	Chr19:18698138-18779584 (-)
CBA/J	MGP_CBAJ_G0024689	protein coding gene	Chr19:20906675-20999913 (-)
DBA/2J	MGP_DBA2J_G0024821	protein coding gene	Chr19:18379294-18460135 (-)
FVB/NJ	MGP_FVBNJ_G0024782	protein coding gene	Chr19:18232999-18316703 (-)
LP/J	MGP_LPJ_G0024905	protein coding gene	Chr19:19396158-19476520 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0024809	protein coding gene	Chr19:21039214-21127759 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0025450	protein coding gene	Chr19:19010370-19095076 (-)
PWK/PhJ	MGP_PWKPhJ_G0023928	protein coding gene	Chr19:17914216-18005523 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0023733	protein coding gene	Chr19:18278685-18364814 (-)
WSB/EiJ	MGP_WSBEiJ_G0024247	protein coding gene	Chr19:19089808-19173600 (-)

Human Ortholog

GDA, guanine deaminase

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GDA, guanine deaminase
Synonyms

CYPIN, GAH, GUANASE, NEDASIN
Links

HGNC:4212

NCBI Gene ID: 9615

neXtProt AC: NX_Q9Y2T3

UniProt: Q9Y2T3
Chr Location

9q21.13; chr9:72114595-72259869 (+) GRCh38

MGI Vertebrate Homology

Gda stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: GDA
Gene Tree

Gda

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Phenotype Summary

12 phenotypes from 1 allele in 1 genetic background
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

1
Targeted

1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

17
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

830
Tissues

104
cDNA Data

59
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas

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All Sequences

68
RefSeq

6
UniProt

9
CCDS

CCDS29698.1

Ensembl

ENSMUSG00000058624 (Evidence)
NCBI Gene

14544

			Length	Strain/Species	Flank
genomic	14544	NCBI Gene Model \| MGI Sequence Detail	81355	C57BL/6J	± kb
transcript	NM_010266	RefSeq \| MGI Sequence Detail	5417	ZRU/MplStud
polypeptide	Q9R111	UniProt \| EBI \| MGI Sequence Detail	454	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000007911 guanine deaminase

(term hierarchy)
EC

3.5.4.3
InterPro Domains

IPR006680 Amidohydrolase-related

IPR014311 Guanine deaminase

IPR032466 Metal-dependent hydrolase

IPR011059 Metal-dependent hydrolase, composite domain superfamily

IPR051607 Metallo-dependent Hydrolases
GlyGen

Q9R111 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)

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All nucleic 61

cDNA 61

Microarray probesets 7

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MGD-MRK-10024, MGI:2147637, MGI:2147689

Summaries

All 44

Developmental Gene Expression 5

Gene Ontology 10

Phenotypes 5
Earliest

J:7470 Bonhomme F, et al., Biochemical diversity and evolution in the genus Mus. Biochem Genet. 1984 Apr;22(3-4):275-303
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Gda:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr158589	Chr19:21449916-21449970 (-)	82 bp
Tssr158588	Chr19:21449876-21449897 (-)	138 bp
Tssr158587	Chr19:21448644-21448646 (-)	1,380 bp
Tssr158586	Chr19:21448552-21448569 (-)	1,464 bp
Tssr158585	Chr19:21448524-21448538 (-)	1,494 bp
Tssr158584	Chr19:21448502-21448513 (-)	1,517 bp
Tssr158583	Chr19:21442553-21442555 (-)	7,471 bp
Tssr5459	Chr19:21438681-21438693 (-)	11,338 bp
Tssr158582	Chr19:21438664-21438673 (-)	11,356 bp
Tssr158581	Chr19:21438246-21438248 (-)	11,778 bp
Tssr158580	Chr19:21434864-21434865 (-)	15,160 bp
Tssr158579	Chr19:21423725-21423730 (-)	26,297 bp
Tssr158578	Chr19:21418253-21418266 (-)	31,765 bp
Tssr158577	Chr19:21418216-21418236 (-)	31,799 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/29/2024 MGI 6.24