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Tyk2 Gene Detail
Summary
  • Symbol
    Tyk2
  • Name
    tyrosine kinase 2
  • Synonyms
    JTK1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1929470
    NCBI Gene: 54721
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:21015364-21042539 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 7.71 cM, cytoband A3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    814 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1929470
 protein coding gene Chr9:21015364-21042689 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034441
 protein coding gene Chr9:18286645-18314858 (-)
A/J MGP_AJ_G0034419
 protein coding gene Chr9:17985636-18012947 (-)
AKR/J MGP_AKRJ_G0034346
 protein coding gene Chr9:18307390-18340741 (-)
BALB/cJ MGP_BALBcJ_G0034410
 protein coding gene Chr9:17878533-17907049 (-)
C3H/HeJ MGP_C3HHeJ_G0034122
 protein coding gene Chr9:18615889-18645306 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034931
 protein coding gene Chr9:19028443-19057746 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031861
 protein coding gene Chr9:17113672-17141417 (-)
CAST/EiJ MGP_CASTEiJ_G0033445
 protein coding gene Chr9:18444217-18470508 (-)
CBA/J MGP_CBAJ_G0034095
 protein coding gene Chr9:19729055-19759536 (-)
DBA/2J MGP_DBA2J_G0034254
 protein coding gene Chr9:17963903-17991301 (-)
FVB/NJ MGP_FVBNJ_G0034197
 protein coding gene Chr9:17475308-17504385 (-)
LP/J MGP_LPJ_G0034339
 protein coding gene Chr9:18460174-18489464 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034240
 protein coding gene Chr9:21351498-21380930 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034951
 protein coding gene Chr9:18253289-18286104 (-)
PWK/PhJ MGP_PWKPhJ_G0033151
 protein coding gene Chr9:17938146-17965785 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032985
 protein coding gene Chr9:18321641-18350980 (-)
WSB/EiJ MGP_WSBEiJ_G0033560
 protein coding gene Chr9:17993010-18020640 (-)



Homology
more
  • Human Ortholog
    TYK2, tyrosine kinase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TYK2, tyrosine kinase 2
  • Synonyms
    IMD35, JTK1
  • Links
    NCBI Gene ID: 7297
    neXtProt AC: NX_P29597
    UniProt: P29597

  • Chr Location
    19p13.2; chr19:10350533-10380608 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tyk2 mouse models; 1 with human TYK2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 5 alleles in 7 genetic backgrounds
    2 phenotypes from multigenic genotypes
    69 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutant mice are viable and fertile, but differ from wild-type with respect to interleukin 12 mediated T cell function.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    15
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032175 Ensembl Gene Model | MGI Sequence Detail 27176 C57BL/6J ±  kb
    transcript ENSMUST00000216874 Ensembl | MGI Sequence Detail 4828 Not Applicable  
    polypeptide ENSMUSP00000150354 Ensembl | MGI Sequence Detail 1207 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 4
    References
    more
    • Summaries
      All 117
      Developmental Gene Expression 2
      Diseases 1
      Gene Ontology 15
      Phenotypes 69
    • Earliest
      J:22208 Ruiz JC, et al., Identification of novel protein kinases expressed in the myocardium of the developing mouse heart. Mech Dev. 1994 Dec;48(3):153-64
    • Latest
      J:351985 Mine K, et al., TYK2 signaling promotes the development of autoreactive CD8(+) cytotoxic T lymphocytes and type 1 diabetes. Nat Commun. 2024 Feb 13;15(1):1337
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory