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Adam25 Gene Detail
Summary
  • Symbol
    Adam25
  • Name
    ADAM metallopeptidase domain 25
  • Synonyms
    testase 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1345157
    NCBI Gene: 23793
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:41205245-41209213 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 23.89 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    157 from dbSNP Build 142
  • Strain Annotations
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1345157
 protein coding gene Chr8:41205245-41209224 (+)
129S1/SvImJ no annotation
A/J MGP_AJ_G0033539
 protein coding gene Chr8:38140282-38143557 (+)
AKR/J MGP_AKRJ_G0033461
 protein coding gene Chr8:39228179-39256789 (+)
BALB/cJ MGP_BALBcJ_G0033534
 protein coding gene Chr8:38213072-38259870 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0034049
 protein coding gene Chr8:41095317-41171395 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030999
 protein coding gene Chr8:34807662-34811607 (+)
CAST/EiJ no annotation
CBA/J no annotation
DBA/2J MGP_DBA2J_G0033376
 protein coding gene Chr8:37947127-37952204 (+)
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    ADAM20, ADAM metallopeptidase domain 20
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ADAM20, ADAM metallopeptidase domain 20
  • Links
    NCBI Gene ID: 8748
    neXtProt AC: NX_O43506
    UniProt: O43506

  • Chr Location
    14q24.2; chr14:70522358-70579452 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    14
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    3
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000071937 Ensembl Gene Model | MGI Sequence Detail 3969 C57BL/6J ±  kb
transcript ENSMUST00000096663 Ensembl | MGI Sequence Detail 2621 Not Applicable  
polypeptide ENSMUSP00000094420 Ensembl | MGI Sequence Detail 760 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 3
    cDNA 3

    Microarray probesets 2
References
more
  • Summaries
    All 21
    Gene Ontology 5
    Phenotypes 2
  • Earliest
    J:56266 Zhu GZ, et al., Identification of four novel ADAMs with potential roles in spermatogenesis and fertilization. Gene. 1999 Jul 8;234(2):227-37
  • Latest
    J:348447 Nguyen TTT, et al., Gene-deficient mouse model established by CRISPR/Cas9 system reveals 15 reproductive organ-enriched genes dispensable for male fertility. Frontiers in Cell and Developmental Biology. 2024;12
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory