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Taf7 Gene Detail
Summary
  • Symbol
    Taf7
  • Name
    TATA-box binding protein associated factor 7
  • Synonyms
    55kDa, Taf2f, TAFII55
  • Feature Type
    protein coding gene
  • IDs
    MGI:1346348
    NCBI Gene: 24074
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:37773544-37777257 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 18, 19.54 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    151 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1346348
 protein coding gene Chr18:37773544-37777257 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024332
 protein coding gene Chr18:36043126-36046838 (-)
A/J MGP_AJ_G0024300
 protein coding gene Chr18:34803809-34807523 (-)
AKR/J MGP_AKRJ_G0024268
 protein coding gene Chr18:35763839-35767550 (-)
BALB/cJ MGP_BALBcJ_G0024299
 protein coding gene Chr18:34873583-34877297 (-)
C3H/HeJ MGP_C3HHeJ_G0024065
 protein coding gene Chr18:35827141-35830864 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024741
 protein coding gene Chr18:37334559-37338272 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022180
 protein coding gene Chr18:34823606-34827338 (-)
CAST/EiJ MGP_CASTEiJ_G0023541
 protein coding gene Chr18:35765461-35769183 (-)
CBA/J MGP_CBAJ_G0024035
 protein coding gene Chr18:38430648-38434362 (-)
DBA/2J MGP_DBA2J_G0024165
 protein coding gene Chr18:34402994-34406708 (-)
FVB/NJ MGP_FVBNJ_G0024131
 protein coding gene Chr18:34118329-34122041 (-)
LP/J MGP_LPJ_G0024249
 protein coding gene Chr18:36118212-36121941 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024162
 protein coding gene Chr18:39717605-39721307 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024790
 protein coding gene Chr18:35618696-35622408 (-)
PWK/PhJ MGP_PWKPhJ_G0023285
 protein coding gene Chr18:34611971-34615798 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023090
 protein coding gene Chr18:35846534-35850269 (-)
WSB/EiJ MGP_WSBEiJ_G0023603
 protein coding gene Chr18:35516400-35520111 (-)



Homology
more
  • Human Ortholog
    TAF7, TATA-box binding protein associated factor 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TAF7, TATA-box binding protein associated factor 7
  • Synonyms
    TAF2F, TAFII55
  • Links
    NCBI Gene ID: 6879
    neXtProt AC: NX_Q15545
    UniProt: Q15545

  • Chr Location
    5q31.3; chr5:141259884-141320784 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 1 genetic background
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality between E3.5 and E5.5. Mice homozygous for a conditional allele activated in thymocytes exhibit impaired T cell differentiation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    71
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    749
  • Tissues
    24
  • cDNA Data
    57
  • Literature Summary
    14
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 24074 NCBI Gene Model | MGI Sequence Detail 3714 C57BL/6J ±  kb
    transcript NM_175770 RefSeq | MGI Sequence Detail 3302 C57BL/6  
    polypeptide Q9R1C0 UniProt | EBI | MGI Sequence Detail 341 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000016033 transcription initiation factor TFIID subunit 7
      (term hierarchy)
    • InterPro Domains
      IPR006751 TAFII55 protein, conserved region
      IPR037817 Transcription initiation factor TFIID subunit 7
    • GlyGen
      Q9R1C0 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 60
      Genomic 1
      cDNA 57
      Primer pair 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2147246, MGI:2147382
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 14
      Gene Ontology 15
      Phenotypes 13
    • Earliest
      J:56830 Wu SY, et al., Isolation of mouse TFIID and functional characterization of TBP and TFIID in mediating estrogen receptor and chromatin transcription. J Biol Chem. 1999 Aug 13;274(33):23480-90
    • Latest
      J:332241 Kobayashi H, et al., Isoform requirement of clustered protocadherin for preventing neuronal apoptosis and neonatal lethality. iScience. 2023 Jan 20;26(1):105766
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    11/05/2024
    MGI 6.24     		The Jackson Laboratory