About   Help   FAQ
Dgke Gene Detail
Summary
  • Symbol
    Dgke
  • Name
    diacylglycerol kinase, epsilon
  • Synonyms
    DAGK6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1889276
    NCBI Gene: 56077
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:88926005-88951644 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 54.34 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    381 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1889276
 protein coding gene Chr11:88926005-88957676 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018930
 protein coding gene Chr11:90801682-90834645 (-)
A/J MGP_AJ_G0018898
 protein coding gene Chr11:87261614-87293419 (-)
AKR/J MGP_AKRJ_G0018868
 protein coding gene Chr11:89937525-89970259 (-)
BALB/cJ MGP_BALBcJ_G0018871
 protein coding gene Chr11:87680979-87714943 (-)
C3H/HeJ MGP_C3HHeJ_G0018685
 protein coding gene Chr11:89960558-89993784 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019323
 protein coding gene Chr11:93590906-93633147 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016954
 protein coding gene Chr11:84284506-84318853 (-)
CAST/EiJ MGP_CASTEiJ_G0018240
 protein coding gene Chr11:90665767-90697989 (-)
CBA/J MGP_CBAJ_G0018656
 protein coding gene Chr11:97572535-97610344 (-)
DBA/2J MGP_DBA2J_G0018764
 protein coding gene Chr11:86808508-86841658 (-)
FVB/NJ MGP_FVBNJ_G0018753
 protein coding gene Chr11:86314271-86345822 (-)
LP/J MGP_LPJ_G0018834
 protein coding gene Chr11:91324535-91357331 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018780
 protein coding gene Chr11:97475862-97509514 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019363
 protein coding gene Chr11:90140650-90174021 (-)
PWK/PhJ MGP_PWKPhJ_G0018010
 protein coding gene Chr11:87676283-87707989 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017800
 protein coding gene Chr11:89721266-89759812 (-)
WSB/EiJ MGP_WSBEiJ_G0018289
 protein coding gene Chr11:90032277-90067742 (-)



Homology
more
  • Human Ortholog
    DGKE, diacylglycerol kinase epsilon
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DGKE, diacylglycerol kinase epsilon
  • Synonyms
    AHUS7, DAGK5, DAGK6, DGK, NPHS7
  • Links
    NCBI Gene ID: 8526
    neXtProt AC: NX_P52429
    UniProt: P52429

  • Chr Location
    17q22; chr17:56834107-56869567 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DGKE associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null allele exhibit reductions in susceptibility to electroconvulsive shock and arachidonoyldiacylglycerol accumulation in cerebral cortex, and attenuated long-term potentiation in dentate granular cell synapses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    708
  • Tissues
    1
  • cDNA Data
    28
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56077 NCBI Gene Model | MGI Sequence Detail 25640 C57BL/6J ±  kb
    transcript NM_019505 RefSeq | MGI Sequence Detail 7611 C57BL/6  
    polypeptide Q9R1C6 UniProt | EBI | MGI Sequence Detail 564 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000006445 diacylglycerol kinase epsilon
      (term hierarchy)
    • EC
      2.7.1.107
    • InterPro Domains
      IPR046349 C1-like domain superfamily
      IPR037607 Diacylglycerol kinase
      IPR000756 Diacylglycerol kinase, accessory domain
      IPR001206 Diacylglycerol kinase, catalytic domain
      IPR017438 Inorganic polyphosphate/ATP-NAD kinase, N-terminal
      IPR016064 NAD kinase/diacylglycerol kinase-like domain superfamily
      IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
    • GlyGen
      Q9R1C6 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 32
      cDNA 30
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2144693
    References
    more
    • Summaries
      All 64
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 8
      Phenotypes 31
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory