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Prpf40a Gene Detail
Summary
  • Symbol
    Prpf40a
  • Name
    pre-mRNA processing factor 40A
  • Synonyms
    2810012K09Rik, FBP11, Fnbp3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1860512
    NCBI Gene: 56194
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:53024714-53081450 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 30.69 cM, cytoband C1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1219 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1860512
 protein coding gene Chr2:53024714-53081714 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025738
 protein coding gene Chr2:52523342-52580917 (-)
A/J MGP_AJ_G0025714
 protein coding gene Chr2:50481373-50537730 (-)
AKR/J MGP_AKRJ_G0025684
 protein coding gene Chr2:51926357-51984258 (-)
BALB/cJ MGP_BALBcJ_G0025709
 protein coding gene Chr2:50586233-50643061 (-)
C3H/HeJ MGP_C3HHeJ_G0025470
 protein coding gene Chr2:51950759-52007902 (-)
C57BL/6NJ MGP_C57BL6NJ_G0026155
 protein coding gene Chr2:54048059-54106173 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023561
 protein coding gene Chr2:48451286-48506697 (-)
CAST/EiJ MGP_CASTEiJ_G0024935
 protein coding gene Chr2:52068813-52125047 (-)
CBA/J MGP_CBAJ_G0025450
 protein coding gene Chr2:56105272-56167006 (-)
DBA/2J MGP_DBA2J_G0025581
 protein coding gene Chr2:50127662-50185168 (-)
FVB/NJ MGP_FVBNJ_G0025543
 protein coding gene Chr2:49814471-49870814 (-)
LP/J MGP_LPJ_G0025669
 protein coding gene Chr2:52423613-52484437 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025574
 protein coding gene Chr2:57102252-57167343 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0026213
 protein coding gene Chr2:51860874-51917501 (-)
PWK/PhJ MGP_PWKPhJ_G0024676
 protein coding gene Chr2:50016737-50073769 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024482
 protein coding gene Chr2:52090276-52147852 (-)
WSB/EiJ MGP_WSBEiJ_G0025002
 protein coding gene Chr2:52150302-52204947 (-)



Homology
more
  • Human Ortholog
    PRPF40A, pre-mRNA processing factor 40 homolog A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PRPF40A, pre-mRNA processing factor 40 homolog A
  • Synonyms
    FBP-11, FBP11, FLAF1, FNBP3, HIP-10, HIP10, HYPA, NY-REN-6, Prp40
  • Links
    NCBI Gene ID: 55660
    neXtProt AC: NX_O75400
    UniProt: O75400

  • Chr Location
    2q23.3; chr2:152651593-152718019 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    844
  • Tissues
    124
  • cDNA Data
    15
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 56194 NCBI Gene Model | MGI Sequence Detail 56737 C57BL/6J ±  kb
    transcript NM_001371015 RefSeq | MGI Sequence Detail 7417 C57BL/6  
    polypeptide Q9R1C7 UniProt | EBI | MGI Sequence Detail 953 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 1
      Other 1

      Microarray probesets 10
    Other
    Accession IDs
    less
    MGI:1922669
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 3
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:38792 Chan DC, et al., Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains. EMBO J. 1996 Mar 1;15(5):1045-54
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory