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Hic1 Gene Detail
Summary
  • Symbol
    Hic1
  • Name
    hypermethylated in cancer 1
  • Synonyms
    HIC-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1338010
    NCBI Gene: 15248
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:75055391-75060345 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 45.76 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    98 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1338010
 protein coding gene Chr11:75052203-75060345 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018704
 protein coding gene Chr11:75896186-75901130 (-)
A/J MGP_AJ_G0018670
 protein coding gene Chr11:73077130-73082075 (-)
AKR/J MGP_AKRJ_G0018640
 protein coding gene Chr11:75292031-75296975 (-)
BALB/cJ MGP_BALBcJ_G0018644
 protein coding gene Chr11:73447818-73452762 (-)
C3H/HeJ MGP_C3HHeJ_G0018457
 protein coding gene Chr11:75305143-75310087 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019095
 protein coding gene Chr11:78271023-78275977 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016730
 protein coding gene Chr11:70093630-70098570 (-)
CAST/EiJ MGP_CASTEiJ_G0018011
 protein coding gene Chr11:75693439-75698390 (-)
CBA/J MGP_CBAJ_G0018427
 protein coding gene Chr11:81708207-81713151 (-)
DBA/2J MGP_DBA2J_G0018536
 protein coding gene Chr11:72683103-72688047 (-)
FVB/NJ MGP_FVBNJ_G0018526
 protein coding gene Chr11:72244397-72249351 (-)
LP/J MGP_LPJ_G0018607
 protein coding gene Chr11:76488956-76493931 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018552
 protein coding gene Chr11:82294469-82299413 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019135
 protein coding gene Chr11:75477699-75482657 (-)
PWK/PhJ MGP_PWKPhJ_G0017782
 protein coding gene Chr11:73379387-73384415 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017573
 protein coding gene Chr11:75047591-75052526 (-)
WSB/EiJ MGP_WSBEiJ_G0018064
 protein coding gene Chr11:75299314-75300307 (-)



Homology
more
  • Human Ortholog
    HIC1, HIC ZBTB transcriptional repressor 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HIC1, HIC ZBTB transcriptional repressor 1
  • Synonyms
    hic-1, ZBTB29, ZNF901
  • Links
    NCBI Gene ID: 3090
    neXtProt AC: NX_Q14526
    UniProt: Q14526

  • Chr Location
    17p13.3; chr17:2054154-2063241 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hic1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    28 phenotypes from 4 alleles in 2 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit varying abnormalities, such as acrania, exencephaly, cleft palate, limb defects, and omphalocele, and die perinatally. Heterozygotes develop tumors, including lymphomas, sarcomas, and epithelial cancers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    974
  • Tissues
    168
  • cDNA Data
    36
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000043099 Ensembl Gene Model | MGI Sequence Detail 4955 C57BL/6J ±  kb
    transcript ENSMUST00000131720 Ensembl | MGI Sequence Detail 3248 Not Applicable  
    polypeptide ENSMUSP00001091661 Ensembl | MGI Sequence Detail 733 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 4
      cDNA 36
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2143980
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 17
      Diseases 1
      Gene Ontology 8
      Phenotypes 34
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:351059 Wang L, et al., T-bet deficiency and Hic1 induction override TGF-beta-dependency in the formation of CD103(+) intestine-resident memory CD8(+) T cells. Cell Rep. 2024 Jun 25;43(6):114258
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory