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Mmp16 Gene Detail
Summary
  • Symbol
    Mmp16
  • Name
    matrix metallopeptidase 16
  • Synonyms
    Membrane type 3-MMP, MT3-MMP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1276107
    NCBI Gene: 17389
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:17853072-18117479 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 7.08 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    7468 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1276107
 protein coding gene Chr4:17852893-18119145 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028077
 protein coding gene Chr4:14806816-15094286 (+)
A/J MGP_AJ_G0028035
 protein coding gene Chr4:14402290-14660567 (+)
AKR/J MGP_AKRJ_G0028000
 protein coding gene Chr4:14680926-14976370 (+)
BALB/cJ MGP_BALBcJ_G0028046
 protein coding gene Chr4:14356023-14625000 (+)
C3H/HeJ MGP_C3HHeJ_G0027776
 protein coding gene Chr4:14831672-15101748 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028489
 protein coding gene Chr4:15402247-15680899 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025831
 protein coding gene Chr4:13388225-13633589 (+)
CAST/EiJ MGP_CASTEiJ_G0027231
 protein coding gene Chr4:14619417-14906292 (+)
CBA/J MGP_CBAJ_G0027749
 protein coding gene Chr4:15834183-16137586 (+)
DBA/2J MGP_DBA2J_G0027892
 protein coding gene Chr4:14203962-14462605 (+)
FVB/NJ MGP_FVBNJ_G0027858
 protein coding gene Chr4:13975573-14240035 (+)
LP/J MGP_LPJ_G0028001
 protein coding gene Chr4:14850273-15128608 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027891
 protein coding gene Chr4:16474452-16887707 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028548
 protein coding gene Chr4:14596286-14872348 (+)
PWK/PhJ MGP_PWKPhJ_G0026951
 protein coding gene Chr4:14169486-14435407 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026780
 protein coding gene Chr4:14513849-14791217 (+)
WSB/EiJ MGP_WSBEiJ_G0027308
 protein coding gene Chr4:14675902-14959385 (+)



Homology
more
  • Human Ortholog
    MMP16, matrix metallopeptidase 16
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MMP16, matrix metallopeptidase 16
  • Synonyms
    C8orf57, MMP-X2, MT3-MMP, MT-MMP2, MT-MMP3
  • Links
    NCBI Gene ID: 4325
    neXtProt AC: NX_P51512
    UniProt: P51512

  • Chr Location
    8q21.3; chr8:88032011-88328025 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    36 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene disruption display normal morphology, clinical chemistry, hematology, and behavior. Mice homozygous for a null allele exhibit reduced skeletal growth.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    940
  • Tissues
    95
  • cDNA Data
    20
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17389 NCBI Gene Model | MGI Sequence Detail 264408 C57BL/6J ±  kb
    transcript NR_166735 RefSeq | MGI Sequence Detail 3483 ZRU/MplStud  
    polypeptide Q9WTR0 UniProt | EBI | MGI Sequence Detail 607 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      cDNA 24
      Primer pair 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 9
      Gene Ontology 6
      Phenotypes 13
    • Earliest
      J:48335 Seldin MF, et al., Mapping of two mouse membrane-type matrix metalloproteinase (MT-MMP) genes, Mmp15 and Mmp16, to mouse chromosomes 8 and 4, respectively. Genomics. 1998 Jun 1;50(2):295-7
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory