Map3k6 MGI Mouse Gene Detail - MGI:1855691 - mitogen-activated protein kinase kinase kinase 6

Symbol

Map3k6
Name

mitogen-activated protein kinase kinase kinase 6
Synonyms

Ask2, MAPKKK6, MEKK6

Feature Type

protein coding gene
IDs

MGI:1855691
NCBI Gene: 53608
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr4:132968129-132980240 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 66.25 cM
Mapping Data

3 experiments

SNPs within 2kb

432 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1855691	protein coding gene	Chr4:132965290-132980240 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0028889	protein coding gene	Chr4:135475570-135487496 (+)
A/J	MGP_AJ_G0028848	protein coding gene	Chr4:129810359-129822413 (+)
AKR/J	MGP_AKRJ_G0028801	protein coding gene	Chr4:133492776-133504830 (+)
BALB/cJ	MGP_BALBcJ_G0028871	protein coding gene	Chr4:130431492-130443541 (+)
C3H/HeJ	MGP_C3HHeJ_G0028585	protein coding gene	Chr4:133744389-133756443 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029313	protein coding gene	Chr4:140346661-140358742 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026584	protein coding gene	Chr4:122891500-122903509 (+)
CAST/EiJ	MGP_CASTEiJ_G0028018	protein coding gene	Chr4:131853555-131865626 (+)
CBA/J	MGP_CBAJ_G0028551	protein coding gene	Chr4:144001082-144013134 (+)
DBA/2J	MGP_DBA2J_G0028700	protein coding gene	Chr4:130230935-130242988 (+)
FVB/NJ	MGP_FVBNJ_G0028667	protein coding gene	Chr4:129102581-129115757 (+)
LP/J	MGP_LPJ_G0028801	protein coding gene	Chr4:135604908-135616969 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028693	protein coding gene	Chr4:148527912-148539978 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029351	protein coding gene	Chr4:133912453-133924516 (+)
PWK/PhJ	MGP_PWKPhJ_G0027739	protein coding gene	Chr4:126940879-126953043 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027565	protein coding gene	Chr4:129756516-129768613 (+)
WSB/EiJ	MGP_WSBEiJ_G0028098	protein coding gene	Chr4:134086147-134098189 (+)

Human Ortholog

MAP3K6, mitogen-activated protein kinase kinase kinase 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAP3K6, mitogen-activated protein kinase kinase kinase 6
Synonyms

ASK2, MAPKKK6, MEKK6
Links

HGNC:6858

NCBI Gene ID: 9064

neXtProt AC: NX_O95382

UniProt: O95382
Chr Location

1p36.11; chr1:27355184-27366961 (-) GRCh38

MGI Vertebrate Homology

Map3k6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MAP3K6
Gene Tree

Map3k6

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
2 phenotypes from multigenic genotypes
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

2
Endonuclease-mediated

2
Radiation induced

1
Targeted

3
Genomic Mutations

4 involving Map3k6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

56 strains or lines available

Homozygous and heterozygous null mice display an increased incidence of chemically induced skin tumors and homozygous mice also show resistance to induced apoptosis.

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All GO Annotations

13
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

790
Tissues

69
cDNA Data

27
Literature Summary

5

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

38
RefSeq

6
UniProt

2
CCDS

CCDS18744.1

Ensembl

ENSMUSG00000028862 (Evidence)
NCBI Gene

53608

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028862	Ensembl Gene Model \| MGI Sequence Detail	12112	C57BL/6J	± kb
transcript	ENSMUST00000030677	Ensembl \| MGI Sequence Detail	4334	Not Applicable
polypeptide	ENSMUSP00000030677	Ensembl \| MGI Sequence Detail	1291	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000010139 mitogen-activated protein kinase kinase kinase 6

(term hierarchy)
EC

2.7.11.25
InterPro Domains

IPR046872 MAP3K, deoxyribohydrolase domain

IPR046873 MAP3K, HisK-N-like globin domain

IPR043969 MAP3K, PH domain

IPR025136 MAP3K, TRAFs-binding domain

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

IPR013761 Sterile alpha motif/pointed domain superfamily

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All nucleic 29

cDNA 28

Primer pair 1

Microarray probesets 4

Summaries

All 45

Developmental Gene Expression 5

Gene Ontology 7

Phenotypes 11
Earliest

J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
Latest

J:262879 Tartey S, et al., ASK1/2 signaling promotes inflammation in a mouse model of neutrophilic dermatosis. J Clin Invest. 2018 May 1;128(5):2042-2047

TSS for Map3k6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr39471	Chr4:132968089-132968138 (+)	-15 bp
Tssr39472	Chr4:132978664-132978699 (+)	10,553 bp
Tssr39473	Chr4:132978721-132978732 (+)	10,598 bp
Tssr39474	Chr4:132978834-132978859 (+)	10,718 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24