Fut8 MGI Mouse Gene Detail - MGI:1858901

Symbol

Fut8
Name

fucosyltransferase 8
Synonyms

alpha (1,6) fucosyltransferase

Feature Type

protein coding gene
IDs

MGI:1858901
NCBI Gene: 53618
Alliance

gene page
Transcription Start Sites

16 TSS

Sequence Map

Chr12:77284878-77522770 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 35.46 cM
Mapping Data

2 experiments

SNPs within 2kb

4747 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1858901	protein coding gene	Chr12:77284878-77523112 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019868	protein coding gene	Chr12:77435204-77689721 (+)
A/J	MGP_AJ_G0019826	protein coding gene	Chr12:74447589-74693270 (+)
AKR/J	MGP_AKRJ_G0019801	protein coding gene	Chr12:76710474-76953642 (+)
BALB/cJ	MGP_BALBcJ_G0019805	protein coding gene	Chr12:74929872-75150058 (+)
C3H/HeJ	MGP_C3HHeJ_G0019611	protein coding gene	Chr12:77178526-77421873 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020257	protein coding gene	Chr12:79773198-80032647 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017875	protein coding gene	Chr12:71773920-71988660 (+)
CAST/EiJ	MGP_CASTEiJ_G0019162	protein coding gene	Chr12:71985677-72233396 (+)
CBA/J	MGP_CBAJ_G0019581	protein coding gene	Chr12:82860320-83123875 (+)
DBA/2J	MGP_DBA2J_G0019697	protein coding gene	Chr12:74321740-74560460 (+)
FVB/NJ	MGP_FVBNJ_G0019684	protein coding gene	Chr12:73135237-73370139 (+)
LP/J	MGP_LPJ_G0019769	protein coding gene	Chr12:77381859-77627356 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019723	protein coding gene	Chr12:85813110-86096359 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020293	protein coding gene	Chr12:76204553-76457755 (+)
PWK/PhJ	MGP_PWKPhJ_G0018928	protein coding gene	Chr12:68674821-68899219 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018722	protein coding gene	Chr12:70687240-70941546 (+)
WSB/EiJ	MGP_WSBEiJ_G0019214	protein coding gene	Chr12:76805792-77043100 (+)

Human Ortholog

FUT8, fucosyltransferase 8

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FUT8, fucosyltransferase 8
Synonyms

CDGF, CDGF1
Links

HGNC:4019

NCBI Gene ID: 2530

neXtProt AC: NX_Q9BYC5

UniProt: Q9BYC5
Chr Location

14q23.3; chr14:65356842-65744121 (+) GRCh38

MGI Vertebrate Homology

Fut8 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: FUT8
Protein SuperFamily

Alpha1_6FUT_euk
Gene Tree

Fut8

Diseases

1 with Fut8 mouse models

Human Disease

Mouse Models

pulmonary emphysema

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

26 phenotypes from 2 alleles in 3 genetic backgrounds
2 images
37 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

5
Targeted

3
Genomic Mutations

1 involving Fut8
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mutation of this gene results in partial postnatal lethality, growth retardation, and progressive emphysema-like changes that include enlarged alveoli, increased lung capacity and compliance, and alveolar cell apoptosis. Postnatal survival is sensitive to genetic background.

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All GO Annotations

23
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

4
cDNA Data

11
Literature Summary

2

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fut8

ZFIN fut8a

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All Sequences

66
RefSeq

9
UniProt

4
CCDS

CCDS25999.1

Ensembl

ENSMUSG00000021065 (Evidence)
NCBI Gene

53618

			Length	Strain/Species	Flank
genomic	53618	NCBI Gene Model \| MGI Sequence Detail	237893	C57BL/6J	± kb
transcript	NR_045554	RefSeq \| MGI Sequence Detail	3342	Not Specified
polypeptide	Q9WTS2	UniProt \| EBI \| MGI Sequence Detail	575	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000007707 alpha-(1,6)-fucosyltransferase

(term hierarchy)
PDB

6VLF, 6VLG
EC

2.4.1.68
InterPro Domains

IPR015827 Alpha-(1,6)-fucosyltransferase

IPR045573 Alpha-(1,6)-fucosyltransferase, N- and catalytic domain

IPR035653 Alpha-(1,6)-fucosyltransferase, SH3 domain

IPR027350 Glycosyltransferase family 23 (GT23) domain

IPR001452 SH3 domain

IPR036028 SH3-like domain superfamily

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All nucleic 13

cDNA 12

Primer pair 1

Microarray probesets 3

Summaries

All 69

Developmental Gene Expression 2

Diseases 1

Gene Ontology 9

Phenotypes 37
Earliest

J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-Le-Grand). 1999 Jul;45(5):737-50
Latest

J:358026 Homan K, et al., Articular cartilage corefucosylation regulates tissue resilience in osteoarthritis. Elife. 2024 Mar 11;12

TSS for Fut8:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr114019	Chr12:77284663-77284684 (+)	-204 bp
Tssr114020	Chr12:77284867-77284896 (+)	4 bp
Tssr3869	Chr12:77285480-77285509 (+)	617 bp
Tssr114021	Chr12:77285514-77285573 (+)	666 bp
Tssr114022	Chr12:77285575-77285605 (+)	712 bp
Tssr114023	Chr12:77285612-77285644 (+)	750 bp
Tssr114024	Chr12:77285770-77285809 (+)	912 bp
Tssr114025	Chr12:77285810-77285848 (+)	951 bp
Tssr114026	Chr12:77285883-77285900 (+)	1,014 bp
Tssr114027	Chr12:77285902-77285916 (+)	1,031 bp
Tssr114028	Chr12:77285927-77285960 (+)	1,066 bp
Tssr114029	Chr12:77286122-77286139 (+)	1,253 bp
Tssr114030	Chr12:77287805-77287809 (+)	2,929 bp
Tssr114031	Chr12:77288121-77288139 (+)	3,252 bp
Tssr114032	Chr12:77378810-77378824 (+)	93,939 bp
Tssr114033	Chr12:77514096-77514100 (+)	229,220 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24