Mapk11 MGI Mouse Gene Detail - MGI:1338024 - mitogen-activated protein kinase 11

Symbol

Mapk11
Name

mitogen-activated protein kinase 11
Synonyms

P38b, p38beta, Prkm11, Sapk2

Feature Type

protein coding gene
IDs

MGI:1338024
NCBI Gene: 19094
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr15:89026685-89033809 bp, - strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 44.66 cM, cytoband E3
Mapping Data

1 experiment

SNPs within 2kb

180 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1338024	protein coding gene	Chr15:89026685-89033831 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0022220	protein coding gene	Chr15:90317124-90324238 (-)
A/J	MGP_AJ_G0022179	protein coding gene	Chr15:86866032-86873151 (-)
AKR/J	MGP_AKRJ_G0022154	protein coding gene	Chr15:89432332-89439452 (-)
BALB/cJ	MGP_BALBcJ_G0022185	protein coding gene	Chr15:86965767-86974463 (-)
C3H/HeJ	MGP_C3HHeJ_G0021955	protein coding gene	Chr15:89420407-89427531 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0022630	protein coding gene	Chr15:93598563-93605618 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020155	protein coding gene	Chr15:83088993-83096282 (-)
CAST/EiJ	MGP_CASTEiJ_G0021477	protein coding gene	Chr15:90204542-90211664 (-)
CBA/J	MGP_CBAJ_G0021922	protein coding gene	Chr15:96759511-96766879 (-)
DBA/2J	MGP_DBA2J_G0022049	protein coding gene	Chr15:86318669-86325785 (-)
FVB/NJ	MGP_FVBNJ_G0022028	protein coding gene	Chr15:85382829-85389942 (-)
LP/J	MGP_LPJ_G0022120	protein coding gene	Chr15:90475586-90482700 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0022048	protein coding gene	Chr15:101182788-101190168 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022645	protein coding gene	Chr15:89467925-89474902 (-)
PWK/PhJ	MGP_PWKPhJ_G0021218	protein coding gene	Chr15:86362484-86369806 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0021052	protein coding gene	Chr15:89201588-89208670 (-)
WSB/EiJ	MGP_WSBEiJ_G0021526	protein coding gene	Chr15:89956054-89963155 (-)

Human Ortholog

MAPK11, mitogen-activated protein kinase 11

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MAPK11, mitogen-activated protein kinase 11
Synonyms

p38-2, P38B, p38Beta, P38BETA2, PRKM11, SAPK2, SAPK2B
Links

HGNC:6873

NCBI Gene ID: 5600

neXtProt AC: NX_Q15759

UniProt: Q15759
Chr Location

22q13.33; chr22:50263713-50270767 (-) GRCh38

MGI Vertebrate Homology

Mapk11 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: MAPK11
Gene Tree

Mapk11

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References

1 with disease annotations

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Phenotype Summary

9 phenotypes from 8 alleles in 7 genetic backgrounds
23 phenotypes from multigenic genotypes
3 images
54 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

22
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Radiation induced

2
Targeted

15
Genomic Mutations

3 involving Mapk11
Incidental Mutations

APF
Find Mice (IMSR)

35 strains or lines available

Mice homozygous for a knock-out allele exhibit a normal phenotype.

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All GO Annotations

37
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

812
Tissues

26
cDNA Data

25
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase mapk11

ZFIN mapk11

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All Sequences

44
RefSeq

2
UniProt

4
CCDS

CCDS27741.1

Ensembl

ENSMUSG00000053137 (Evidence)
NCBI Gene

19094

			Length	Strain/Species	Flank
genomic	19094	NCBI Gene Model \| MGI Sequence Detail	7125	C57BL/6J	± kb
transcript	NM_011161	RefSeq \| MGI Sequence Detail	2452	C57BL/6
polypeptide	Q9WUI1	UniProt \| EBI \| MGI Sequence Detail	364	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000010152 mitogen-activated protein kinase 11

(term hierarchy)
EC

2.7.11.24
InterPro Domains

IPR050117 Mitogen-activated protein kinase

IPR003527 Mitogen-activated protein (MAP) kinase, conserved site

IPR008352 Mitogen-activated protein (MAP) kinase p38-like

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

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All nucleic 27

Genomic 1

cDNA 25

Primer pair 1

Microarray probesets 7

Summaries

All 106

Developmental Gene Expression 9

Diseases 1

Gene Ontology 12

Phenotypes 54
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Mapk11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr135844	Chr15:89033760-89033853 (-)	2 bp
Tssr135843	Chr15:89031352-89031398 (-)	2,434 bp
Tssr135842	Chr15:89031231-89031267 (-)	2,560 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24