Orc6 MGI Mouse Gene Detail - MGI:1929285 - origin recognition complex, subunit 6

Symbol

Orc6
Name

origin recognition complex, subunit 6
Synonyms

6720420I10Rik, Orc6l

Feature Type

protein coding gene
IDs

MGI:1929285
NCBI Gene: 56452
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr8:86026261-86034907 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 41.61 cM, cytoband C3
Mapping Data

3 experiments

SNPs within 2kb

225 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1929285	protein coding gene	Chr8:86026261-86034908 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033899	protein coding gene	Chr8:86222249-86232760 (+)
A/J	MGP_AJ_G0033882	protein coding gene	Chr8:82821517-82829665 (+)
AKR/J	MGP_AKRJ_G0033808	protein coding gene	Chr8:85286990-85295657 (+)
BALB/cJ	MGP_BALBcJ_G0033875	protein coding gene	Chr8:82965079-82973918 (+)
C3H/HeJ	MGP_C3HHeJ_G0033586	protein coding gene	Chr8:85907313-85915461 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034396	protein coding gene	Chr8:89569604-89577753 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031336	protein coding gene	Chr8:76615856-76624408 (+)
CAST/EiJ	MGP_CASTEiJ_G0032915	protein coding gene	Chr8:85337125-85345787 (+)
CBA/J	MGP_CBAJ_G0033561	protein coding gene	Chr8:92575427-92583575 (+)
DBA/2J	MGP_DBA2J_G0033714	protein coding gene	Chr8:82463490-82471638 (+)
FVB/NJ	MGP_FVBNJ_G0033662	protein coding gene	Chr8:81417048-81425167 (+)
LP/J	MGP_LPJ_G0033806	protein coding gene	Chr8:86336908-86346427 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033705	protein coding gene	Chr8:95123928-95132077 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034413	protein coding gene	Chr8:85294886-85303035 (+)
PWK/PhJ	MGP_PWKPhJ_G0032619	protein coding gene	Chr8:81715859-81724127 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032455	protein coding gene	Chr8:84089378-84097540 (+)
WSB/EiJ	MGP_WSBEiJ_G0033028	protein coding gene	Chr8:85708711-85717351 (+)

Human Ortholog

ORC6, origin recognition complex subunit 6

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ORC6, origin recognition complex subunit 6
Synonyms

ORC6L
Links

HGNC:17151

NCBI Gene ID: 23594

neXtProt AC: NX_Q9Y5N6

UniProt: Q9Y5N6
Chr Location

16q11.2; chr16:46689643-46698394 (+) GRCh38

MGI Vertebrate Homology

Orc6 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ORC6
Gene Tree

Orc6

Diseases

1 with human ORC6 associations

				Human Disease	Mouse Models
				Meier-Gorlin syndrome 3 IDs Meier-Gorlin syndrome 3 DOID:0080514 OMIM:613803

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

11 phenotypes from 1 allele in 1 genetic background
1 images
40 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

17
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

14
Radiation induced

1
Genomic Mutations

2 involving Orc6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele show complete embryonic lethality before implantation associated with abnormal morula morphology, increased cell death, and failure of blastocyst formation.

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All GO Annotations

11
GO References

6

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

814
Tissues

25
cDNA Data

8
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase orc6

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All Sequences

54
RefSeq

5
UniProt

6
CCDS

CCDS22497.1, CCDS52623.1

Ensembl

ENSMUSG00000031697 (Evidence)
NCBI Gene

56452

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031697	Ensembl Gene Model \| MGI Sequence Detail	8647	C57BL/6J	± kb
transcript	ENSMUST00000034132	Ensembl \| MGI Sequence Detail	1287	Not Applicable
polypeptide	ENSMUSP00000034132	Ensembl \| MGI Sequence Detail	262	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000012035 origin recognition complex subunit 6

(term hierarchy)
InterPro Domains

IPR008721 Origin recognition complex, subunit 6

IPR020529 Origin recognition complex, subunit 6, metazoa/plant

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All nucleic 9

cDNA 8

Primer pair 1

Microarray probesets 4

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MGI:1924394

Summaries

All 68

Developmental Gene Expression 2

Gene Ontology 6

Phenotypes 40
Earliest

J:13049 Gruneberg H, Genetical studies on the skeleton of the mouse. XVIII. Three genes for syndactylism. J Genet. 1956;54(1):113-145
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Orc6:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr78546	Chr8:86026274-86026296 (+)	24 bp
Tssr78547	Chr8:86026325-86026335 (+)	69 bp
Tssr78548	Chr8:86026521-86026557 (+)	278 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24