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Cxcl14 Gene Detail
Summary
  • Symbol
    Cxcl14
  • Name
    C-X-C motif chemokine ligand 14
  • Synonyms
    1110031L23Rik, 1200006I23Rik, BRAK, Kec, MIP-2g, Scyb14
  • Feature Type
    protein coding gene
  • IDs
    MGI:1888514
    NCBI Gene: 57266
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:56436456-56444364 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 30.06 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    339 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1888514
 protein coding gene Chr13:56436456-56444624 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020616
 protein coding gene Chr13:55826931-55834836 (-)
A/J MGP_AJ_G0020570
 protein coding gene Chr13:53757897-53765803 (-)
AKR/J MGP_AKRJ_G0020548
 protein coding gene Chr13:55350357-55358261 (-)
BALB/cJ MGP_BALBcJ_G0020566
 protein coding gene Chr13:53988937-53996841 (-)
C3H/HeJ MGP_C3HHeJ_G0020365
 protein coding gene Chr13:55155883-55163787 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021000
 protein coding gene Chr13:57525211-57533115 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018582
 protein coding gene Chr13:51687719-51695568 (-)
CAST/EiJ MGP_CASTEiJ_G0019879
 protein coding gene Chr13:55272889-55280778 (-)
CBA/J MGP_CBAJ_G0020325
 protein coding gene Chr13:59711535-59719439 (-)
DBA/2J MGP_DBA2J_G0020448
 protein coding gene Chr13:53303132-53311605 (-)
FVB/NJ MGP_FVBNJ_G0020427
 protein coding gene Chr13:52771134-52779038 (-)
LP/J MGP_LPJ_G0020524
 protein coding gene Chr13:56086256-56094153 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020456
 protein coding gene Chr13:59137027-59144930 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021043
 protein coding gene Chr13:54940164-54948068 (-)
PWK/PhJ MGP_PWKPhJ_G0019635
 protein coding gene Chr13:53336029-53344268 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019462
 protein coding gene Chr13:53881791-53889735 (-)
WSB/EiJ MGP_WSBEiJ_G0019941
 protein coding gene Chr13:55299112-55307018 (-)



Homology
more
  • Human Ortholog
    CXCL14, C-X-C motif chemokine ligand 14
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CXCL14, C-X-C motif chemokine ligand 14
  • Synonyms
    BMAC, BRAK, KEC, KS1, MIP-2g, MIP2G, NJAC, SCYB14
  • Links
    NCBI Gene ID: 9547
    neXtProt AC: NX_O95715
    UniProt: O95715

  • Chr Location
    5q31.1; chr5:135570679-135579279 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 4 alleles in 4 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutant cause partial lethality before weaning, however surviving null are small but fertile and show insulin-sensitive phenotype in female under high fat diet feeding condition.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    12
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    954
  • Tissues
    175
  • cDNA Data
    93
  • Literature Summary
    23
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021508 Ensembl Gene Model | MGI Sequence Detail 7909 C57BL/6J ±  kb
    transcript ENSMUST00000021970 Ensembl | MGI Sequence Detail 1827 Not Applicable  
    polypeptide ENSMUSP00000021970 Ensembl | MGI Sequence Detail 99 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 107
      Genomic 2
      cDNA 94
      Primer pair 8
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1915056, MGI:1915961, MGI:2145226
    References
    more
    • Summaries
      All 85
      Developmental Gene Expression 23
      Gene Ontology 8
      Phenotypes 22
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:353798 Iannone AF, et al., The chemokine Cxcl14 regulates interneuron differentiation in layer I of the somatosensory cortex. Cell Rep. 2024 Aug 27;43(8):114531
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory