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Hnf4g Gene Detail
Summary
  • Symbol
    Hnf4g
  • Name
    hepatocyte nuclear factor 4, gamma
  • Synonyms
    NR2A2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1353604
    NCBI Gene: 30942
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:3573090-3724863 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 1.82 cM, cytoband A
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    4205 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1353604
 protein coding gene Chr3:3573084-3724863 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027043
 protein coding gene Chr3:251538-413141 (+)
A/J MGP_AJ_G0027007
 protein coding gene Chr3:594687-754225 (+)
AKR/J MGP_AKRJ_G0026978
 protein coding gene Chr3:363208-531385 (+)
BALB/cJ MGP_BALBcJ_G0027016
 protein coding gene Chr3:304252-481453 (+)
C3H/HeJ MGP_C3HHeJ_G0026757
 protein coding gene Chr3:595317-760273 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027461
 protein coding gene Chr3:596785-787252 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024824
 protein coding gene Chr3:143551-282532 (+)
CAST/EiJ MGP_CASTEiJ_G0026215
 protein coding gene Chr3:634010-815684 (+)
CBA/J MGP_CBAJ_G0026735
 protein coding gene Chr3:256538-426495 (+)
DBA/2J MGP_DBA2J_G0026871
 protein coding gene Chr3:243455-396407 (+)
FVB/NJ MGP_FVBNJ_G0026838
 protein coding gene Chr3:229583-383441 (+)
LP/J MGP_LPJ_G0026974
 protein coding gene Chr3:585226-754462 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026858
 protein coding gene Chr3:550500-729967 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027521
 protein coding gene Chr3:230033-385962 (+)
PWK/PhJ MGP_PWKPhJ_G0025951
 protein coding gene Chr3:572421-730106 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025753
 protein coding gene Chr3:457560-629402 (+)
WSB/EiJ MGP_WSBEiJ_G0026287
 protein coding gene Chr3:227026-392410 (+)



Homology
more
  • Human Ortholog
    HNF4G, hepatocyte nuclear factor 4 gamma
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HNF4G, hepatocyte nuclear factor 4 gamma
  • Synonyms
    NR2A2, NR2A3
  • Links
    NCBI Gene ID: 3174
    neXtProt AC: NX_Q14541
    UniProt: Q14541

  • Chr Location
    8q21.13; chr8:75407649-75566834 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are less inclined to build nests, spend more time in a passive state during the forced swim test, and display a reduction in energy expenditure and night time activity that results in increased body weight despite adecreased intake of food and water.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    844
  • Tissues
    82
  • cDNA Data
    9
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 30942 NCBI Gene Model | MGI Sequence Detail 151774 C57BL/6J ±  kb
    transcript NM_013920 RefSeq | MGI Sequence Detail 4183 C57BL/6  
    polypeptide Q9WUU6 UniProt | EBI | MGI Sequence Detail 408 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000008655 hepatocyte nuclear factor 4-gamma
      (term hierarchy)
    • InterPro Domains
      IPR049635 Hepatocyte nuclear factor 4, ligand-binding domain
      IPR049636 Hepatocyte nuclear factor 4-like, DNA-binding domain
      IPR001723 Nuclear hormone receptor
      IPR050274 Nuclear hormone receptor family NR2 subfamily
      IPR000536 Nuclear hormone receptor, ligand-binding domain
      IPR035500 Nuclear hormone receptor-like domain superfamily
      IPR013088 Zinc finger, NHR/GATA-type
      IPR001628 Zinc finger, nuclear hormone receptor-type
    Molecular
    Reagents
    less
    • All nucleic 11
      Genomic 1
      cDNA 9
      Primer pair 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 13
      Gene Ontology 5
      Phenotypes 16
    • Earliest
      J:60242 Taraviras S, et al., Primary structure, chromosomal mapping, expression and transcriptional activity of murine hepatocyte nuclear factor 4gamma. Biochim Biophys Acta. 2000 Jan 31;1490(1-2):21-32
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    10/29/2024
    MGI 6.24     		The Jackson Laboratory