Ccl17 MGI Mouse Gene Detail - MGI:1329039 - C-C motif chemokine ligand 17

Symbol

Ccl17
Name

C-C motif chemokine ligand 17
Synonyms

ABCD-2, Scya17, TARC

Feature Type

protein coding gene
IDs

MGI:1329039
NCBI Gene: 20295
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr8:95537081-95538664 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 46.85 cM
Mapping Data

4 experiments

SNPs within 2kb

126 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1329039	protein coding gene	Chr8:95535996-95538666 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033969	protein coding gene	Chr8:96245314-96246896 (+)
A/J	MGP_AJ_G0033952	protein coding gene	Chr8:92499392-92500974 (+)
AKR/J	MGP_AKRJ_G0033878	protein coding gene	Chr8:95017617-95019199 (+)
BALB/cJ	MGP_BALBcJ_G0033944	protein coding gene	Chr8:92579038-92580620 (+)
C3H/HeJ	MGP_C3HHeJ_G0033654	protein coding gene	Chr8:95730534-95732116 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034465	protein coding gene	Chr8:99748076-99749658 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031406	protein coding gene	Chr8:86302645-86304212 (+)
CAST/EiJ	MGP_CASTEiJ_G0032986	protein coding gene	Chr8:95332954-95334536 (+)
CBA/J	MGP_CBAJ_G0033630	protein coding gene	Chr8:103040273-103041855 (+)
DBA/2J	MGP_DBA2J_G0033784	protein coding gene	Chr8:91956805-91958387 (+)
FVB/NJ	MGP_FVBNJ_G0033731	protein coding gene	Chr8:90924586-90926168 (+)
LP/J	MGP_LPJ_G0033876	protein coding gene	Chr8:96394952-96396534 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033773	protein coding gene	Chr8:105337762-105339344 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034483	protein coding gene	Chr8:95184494-95186076 (+)
PWK/PhJ	MGP_PWKPhJ_G0032688	protein coding gene	Chr8:91345088-91346670 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032525	protein coding gene	Chr8:94018860-94020456 (+)
WSB/EiJ	MGP_WSBEiJ_G0033098	protein coding gene	Chr8:95715344-95716926 (+)

Human Ortholog

CCL17, C-C motif chemokine ligand 17

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CCL17, C-C motif chemokine ligand 17
Synonyms

A-152E5.3, ABCD-2, SCYA17, TARC
Links

HGNC:10615

NCBI Gene ID: 6361

neXtProt AC: NX_Q92583

UniProt: Q92583
Chr Location

16q21; chr16:57396093-57416063 (+) GRCh38

MGI Vertebrate Homology

Ccl17 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CCL17
Gene Tree

Ccl17

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
6 phenotypes from multigenic genotypes
33 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Endonuclease-mediated

7
Gene trapped

1
Targeted

4
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit decreased contact hypersensitivity and increased allograft survival.

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All GO Annotations

13
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

765
Tissues

37
cDNA Data

9
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

34
RefSeq

4
UniProt

2
CCDS

CCDS57633.1

Ensembl

ENSMUSG00000031780 (Evidence)
NCBI Gene

20295

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031780	Ensembl Gene Model \| MGI Sequence Detail	1584	C57BL/6J	± kb
transcript	ENSMUST00000034232	Ensembl \| MGI Sequence Detail	514	Not Applicable
polypeptide	ENSMUSP00000034232	Ensembl \| MGI Sequence Detail	103	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000001989 C-C motif chemokine 17

(term hierarchy)
InterPro Domains

IPR000827 CC chemokine, conserved site

IPR039809 Chemokine beta/gamma/delta

IPR001811 Chemokine interleukin-8-like domain

IPR036048 Chemokine interleukin-8-like superfamily

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All nucleic 12

cDNA 9

Primer pair 3

Microarray probesets 3

Summaries

All 88

Developmental Gene Expression 9

Gene Ontology 7

Phenotypes 33
Earliest

J:51316 Yoneyama H, et al., Pivotal role of TARC, a CC chemokine, in bacteria-induced fulminant hepatic failure in mice. J Clin Invest. 1998 Dec 1;102(11):1933-41
Latest

J:350739 Heine A, et al., Rapid protection against viral infections by chemokine-accelerated post-exposure vaccination. Front Immunol. 2024;15:1338499

TSS for Ccl17:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr78920	Chr8:95537074-95537089 (+)	1 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 10/22/2024 MGI 6.24