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Apobec2 Gene Detail
Summary
  • Symbol
    Apobec2
  • Name
    apolipoprotein B mRNA editing enzyme, catalytic polypeptide 2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1343178
    NCBI Gene: 11811
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:48726259-48739756 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 24.02 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    598 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1343178
 protein coding gene Chr17:48726259-48739958 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023873
 protein coding gene Chr17:49712145-49725630 (-)
A/J MGP_AJ_G0023833
 protein coding gene Chr17:48398294-48412949 (-)
AKR/J MGP_AKRJ_G0023801
 protein coding gene Chr17:48886182-48899608 (-)
BALB/cJ MGP_BALBcJ_G0023835
 protein coding gene Chr17:48322096-48335699 (-)
C3H/HeJ MGP_C3HHeJ_G0023598
 protein coding gene Chr17:49590030-49605078 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024278
 protein coding gene Chr17:51820617-51833920 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021727
 protein coding gene Chr17:45154189-45167763 (-)
CAST/EiJ MGP_CASTEiJ_G0023080
 protein coding gene Chr17:49774994-49787292 (-)
CBA/J MGP_CBAJ_G0023574
 protein coding gene Chr17:53681989-53698547 (-)
DBA/2J MGP_DBA2J_G0023703
 protein coding gene Chr17:47168243-47182528 (-)
FVB/NJ MGP_FVBNJ_G0023669
 protein coding gene Chr17:46829585-46843382 (-)
LP/J MGP_LPJ_G0023783
 protein coding gene Chr17:50416613-50431095 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023697
 protein coding gene Chr17:53162557-53177188 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024324
 protein coding gene Chr17:49217414-49235675 (-)
PWK/PhJ MGP_PWKPhJ_G0022825
 protein coding gene Chr17:46602269-46616684 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022639
 protein coding gene Chr17:46122911-46137431 (-)
WSB/EiJ MGP_WSBEiJ_G0023144
 protein coding gene Chr17:49814237-49827622 (-)



Homology
more
  • Human Ortholog
    APOBEC2, apolipoprotein B mRNA editing enzyme catalytic subunit 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APOBEC2, apolipoprotein B mRNA editing enzyme catalytic subunit 2
  • Synonyms
    ARCD1, ARP1
  • Links
    NCBI Gene ID: 10930
    neXtProt AC: NX_Q9Y235
    UniProt: Q9Y235

  • Chr Location
    6p21.1; chr6:41053202-41064891 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 3 genetic backgrounds
    1 images
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trapped allele display growth retardation and decreased bone mineralization and density. Mice homozygous for a knockout allele exhibit reduced body mass and a shift in muscle fiber type and develop a mild myopathy as as they age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    852
  • Tissues
    99
  • cDNA Data
    45
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11811 NCBI Gene Model | MGI Sequence Detail 13498 C57BL/6J ±  kb
    transcript NM_009694 RefSeq | MGI Sequence Detail 1218 ZRU/MplStud  
    polypeptide Q9WV35 UniProt | EBI | MGI Sequence Detail 224 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 48
      cDNA 46
      Primer pair 2

      Microarray probesets 6
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 4
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:32731 Hirano K, et al., Targeted disruption of the mouse apobec-1 gene abolishes apolipoprotein B mRNA editing and eliminates apolipoprotein B48. J Biol Chem. 1996 Apr 26;271(17):9887-90
    • Latest
      J:311508 Florkowska A, et al., PAX7 Balances the Cell Cycle Progression via Regulating Expression of Dnmt3b and Apobec2 in Differentiating PSCs. Cells. 2021 Aug 26;10(9)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory