Katna1 MGI Mouse Gene Detail - MGI:1344353 - katanin p60 (ATPase-containing) subunit A1

Symbol

Katna1
Name

katanin p60 (ATPase-containing) subunit A1

Feature Type

protein coding gene
IDs

MGI:1344353
NCBI Gene: 23924
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr10:7601764-7638914 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 10, 2.32 cM, cytoband A1
Mapping Data

2 experiments

SNPs within 2kb

1093 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1344353	protein coding gene	Chr10:7601748-7638914 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0016998	protein coding gene	Chr10:4951062-4989003 (+)
A/J	MGP_AJ_G0016976	protein coding gene	Chr10:4703670-4741508 (+)
AKR/J	MGP_AKRJ_G0016940	protein coding gene	Chr10:4795820-4835165 (+)
BALB/cJ	MGP_BALBcJ_G0016934	protein coding gene	Chr10:4677249-4713954 (+)
C3H/HeJ	MGP_C3HHeJ_G0016759	protein coding gene	Chr10:4929295-4967238 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0017396	protein coding gene	Chr10:5060251-5104469 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015101	protein coding gene	Chr10:4296932-4334887 (+)
CAST/EiJ	MGP_CASTEiJ_G0016341	protein coding gene	Chr10:4834867-4884639 (+)
CBA/J	MGP_CBAJ_G0016731	protein coding gene	Chr10:5214464-5257931 (+)
DBA/2J	MGP_DBA2J_G0016839	protein coding gene	Chr10:4634166-4670417 (+)
FVB/NJ	MGP_FVBNJ_G0016834	protein coding gene	Chr10:4581876-4617989 (+)
LP/J	MGP_LPJ_G0016914	protein coding gene	Chr10:4793585-4832390 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0016864	protein coding gene	Chr10:5176993-5214425 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0017434	protein coding gene	Chr10:4750092-4788883 (+)
PWK/PhJ	MGP_PWKPhJ_G0016126	protein coding gene	Chr10:4606779-4643722 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0015908	protein coding gene	Chr10:4828401-4862946 (+)
WSB/EiJ	MGP_WSBEiJ_G0016403	protein coding gene	Chr10:4751806-4790030 (+)

Human Ortholog

KATNA1, katanin catalytic subunit A1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KATNA1, katanin catalytic subunit A1
Links

HGNC:6216

NCBI Gene ID: 11104

neXtProt AC: NX_O75449

UniProt: O75449
Chr Location

6q25.1; chr6:149594873-149648990 (-) GRCh38

MGI Vertebrate Homology

Katna1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: KATNA1
Gene Tree

Katna1

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Phenotype Summary

11 phenotypes from 2 alleles in 2 genetic backgrounds
12 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

16
Endonuclease-mediated

2
Gene trapped

12
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

30 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit complete prenatal lethality. Heterozygous null mice exhibit altered neuronal progenitor proliferation in the developing cortex and during adult hippocampal neurogenesis.

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All GO Annotations

46
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

723
Tissues

15
cDNA Data

9
Literature Summary

7

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase katna1

ZFIN katna1

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All Sequences

53
RefSeq

6
UniProt

6
CCDS

CCDS23689.2

Ensembl

ENSMUSG00000019794 (Evidence)
NCBI Gene

23924

			Length	Strain/Species	Flank
genomic	ENSMUSG00000019794	Ensembl Gene Model \| MGI Sequence Detail	37151	C57BL/6J	± kb
transcript	ENSMUST00000165806	Ensembl \| MGI Sequence Detail	1775	Not Applicable
polypeptide	ENSMUSP00000132514	Ensembl \| MGI Sequence Detail	493	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000009242 katanin p60 ATPase-containing subunit A1

(term hierarchy)
PDB

2RPA, 5LB7, 5NBT, 5OW5, 6GZC
EC

5.6.1.1
InterPro Domains

IPR041569 AAA ATPase, AAA+ lid domain

IPR003593 AAA+ ATPase domain

IPR003960 ATPase, AAA-type, conserved site

IPR003959 ATPase, AAA-type, core

IPR048612 Katanin p60 ATPase-containing subunit A1, AAA domain

IPR048611 Katanin p60 ATPase-containing subunit A1, MIT domain

IPR028596 Katanin p60 subunit A1

IPR050304 Microtubule-severing AAA ATPase

IPR036181 MIT domain superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR015415 Spastin/Vps4, C-terminal

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All nucleic 10

cDNA 9

Primer pair 1

Microarray probesets 3

Summaries

All 51

Developmental Gene Expression 7

Gene Ontology 13

Phenotypes 12
Earliest

J:56613 Syu LJ, et al., Lipotransin: a novel docking protein for hormone-sensitive lipase. Mol Cell. 1999 Jul;4(1):109-15
Latest

J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

TSS for Katna1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr92312	Chr10:7601761-7601778 (+)	6 bp
Tssr92313	Chr10:7601825-7601847 (+)	72 bp
Tssr92314	Chr10:7602445-7602458 (+)	688 bp
Tssr92315	Chr10:7629327-7629339 (+)	27,569 bp
Tssr92316	Chr10:7634458-7634465 (+)	32,698 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24