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Pla2g2d Gene Detail
Summary
  • Symbol
    Pla2g2d
  • Name
    phospholipase A2, group IID
  • Synonyms
    mGIID, Splash
  • Feature Type
    protein coding gene
  • IDs
    MGI:1341796
    NCBI Gene: 18782
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:138503046-138509357 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 70.57 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    340 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1341796
 protein coding gene Chr4:138503046-138509363 (+)
129S1/SvImJ MGP_129S1SvImJ_G0029003
 protein coding gene Chr4:141560535-141568075 (+)
A/J MGP_AJ_G0028962
 protein coding gene Chr4:135484157-135491187 (+)
AKR/J MGP_AKRJ_G0028914
 protein coding gene Chr4:139362422-139368710 (+)
BALB/cJ MGP_BALBcJ_G0028986
 protein coding gene Chr4:136160127-136166825 (+)
C3H/HeJ MGP_C3HHeJ_G0028700
 protein coding gene Chr4:139735061-139741336 (+)
C57BL/6NJ MGP_C57BL6NJ_G0029427
 protein coding gene Chr4:146562441-146568783 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026698
 protein coding gene Chr4:128465299-128471576 (+)
CAST/EiJ MGP_CASTEiJ_G0028132
 protein coding gene Chr4:137905547-137910909 (+)
CBA/J MGP_CBAJ_G0028665
 protein coding gene Chr4:150786257-150792545 (+)
DBA/2J MGP_DBA2J_G0028814
 protein coding gene Chr4:135867004-135873293 (+)
FVB/NJ MGP_FVBNJ_G0028781
 protein coding gene Chr4:134895194-134902062 (+)
LP/J MGP_LPJ_G0028913
 protein coding gene Chr4:141636019-141643930 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028807
 protein coding gene Chr4:154745836-154752199 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0029465
 protein coding gene Chr4:139894745-139901062 (+)
PWK/PhJ MGP_PWKPhJ_G0027853
 protein coding gene Chr4:132724972-132730327 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027678
 protein coding gene Chr4:135645592-135651938 (+)
WSB/EiJ MGP_WSBEiJ_G0028210
 protein coding gene Chr4:140130705-140136991 (+)



Homology
more
  • Human Ortholog
    PLA2G2D, phospholipase A2 group IID
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PLA2G2D, phospholipase A2 group IID
  • Synonyms
    PLA2IID, sPLA2-IID, sPLA2S, SPLASH
  • Links
    NCBI Gene ID: 26279
    neXtProt AC: NX_Q9UNK4
    UniProt: Q9UNK4

  • Chr Location
    1p36.12; chr1:20111939-20119566 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 2 alleles in 3 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired resolution of hapten-induced contact hypersensitivity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    26
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    828
  • Tissues
    111
  • cDNA Data
    26
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000041202 Ensembl Gene Model | MGI Sequence Detail 6312 C57BL/6J ±  kb
    transcript ENSMUST00000030528 Ensembl | MGI Sequence Detail 2167 Not Applicable  
    polypeptide ENSMUSP00000030528 Ensembl | MGI Sequence Detail 144 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      cDNA 26
      Primer pair 2
      Other 1

      Microarray probesets 6
    References
    more
    • Summaries
      All 52
      Developmental Gene Expression 5
      Gene Ontology 9
      Phenotypes 16
    • Earliest
      J:56018 Valentin E, et al., Cloning and recombinant expression of a novel mouse-secreted phospholipase A2. J Biol Chem. 1999 Jul 2;274(27):19152-60
    • Latest
      J:353367 Taketomi Y, et al., Lipid-orchestrated paracrine circuit coordinates mast cell maturation and anaphylaxis through functional interaction with fibroblasts. Immunity. 2024 Aug 13;57(8):1828-1847.e11
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory