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Bcl2l10 Gene Detail
Summary
  • Symbol
    Bcl2l10
  • Name
    Bcl2-like 10
  • Synonyms
    Boo, Diva
  • Feature Type
    protein coding gene
  • IDs
    MGI:1330841
    NCBI Gene: 12049
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:75255040-75258922 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 42.30 cM, cytoband D
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    187 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1330841
 protein coding gene Chr9:75255040-75258931 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035037
 protein coding gene Chr9:75645370-75649252 (+)
A/J MGP_AJ_G0035018
 protein coding gene Chr9:73000304-73004165 (+)
AKR/J MGP_AKRJ_G0034947
 protein coding gene Chr9:74756156-74759894 (+)
BALB/cJ MGP_BALBcJ_G0035010
 protein coding gene Chr9:72685893-72689765 (+)
C3H/HeJ MGP_C3HHeJ_G0034719
 protein coding gene Chr9:75220434-75224267 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035529
 protein coding gene Chr9:77665880-77669753 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032440
 protein coding gene Chr9:72372757-72377233 (+)
CAST/EiJ MGP_CASTEiJ_G0034041
 protein coding gene Chr9:75565123-75568962 (+)
CBA/J MGP_CBAJ_G0034692
 protein coding gene Chr9:80316667-80320535 (+)
DBA/2J MGP_DBA2J_G0034851
 protein coding gene Chr9:72681866-72685738 (+)
FVB/NJ MGP_FVBNJ_G0034793
 protein coding gene Chr9:71984543-71988414 (+)
LP/J MGP_LPJ_G0034932
 protein coding gene Chr9:75902206-75906085 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034834
 protein coding gene Chr9:81412789-81416635 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035551
 protein coding gene Chr9:74909448-74913330 (+)
PWK/PhJ MGP_PWKPhJ_G0033745
 protein coding gene Chr9:72964964-72968796 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033578
 protein coding gene Chr9:75142793-75146616 (+)
WSB/EiJ MGP_WSBEiJ_G0034153
 protein coding gene Chr9:74829316-74833185 (+)



Homology
more
  • Human Ortholog
    BCL2L10, BCL2 like 10
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    BCL2L10, BCL2 like 10
  • Synonyms
    bcl2-L-10, BCL-B, Boo, Diva
  • Links
    NCBI Gene ID: 10017
    neXtProt AC: NX_Q9HD36
    UniProt: Q9HD36

  • Chr Location
    15q21.2; chr15:52109263-52112775 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human BCL2L10 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    4 phenotype references
Mice homozygous for a targeted mutation exhibit no obvious abnormalities. They are viable and fertile with normal reproductive capacity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    34
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    861
  • Tissues
    60
  • cDNA Data
    68
  • Literature Summary
    7
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 12049 NCBI Gene Model | MGI Sequence Detail 3883 C57BL/6J ±  kb
transcript NM_013479 RefSeq | MGI Sequence Detail 1228 C57BL/6  
polypeptide Q9Z0F3 UniProt | EBI | MGI Sequence Detail 191 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 73
    Genomic 1
    cDNA 69
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGI:2142940, MGI:2143221, MGI:2143426
References
more
  • Summaries
    All 36
    Developmental Gene Expression 7
    Gene Ontology 9
    Phenotypes 4
  • Earliest
    J:51315 Inohara N, et al., Diva, a Bcl-2 homologue that binds directly to Apaf-1 and induces BH3-independent cell death. J Biol Chem. 1998 Dec 4;273(49):32479-86
  • Latest
    J:331481 Liu Y, et al., Expression patterns and biological function of BCL2L10 during mouse preimplantation development. Gene Expr Patterns. 2022 Dec;46:119285
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory