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Ggh Gene Detail
Summary
  • Symbol
    Ggh
  • Name
    gamma-glutamyl hydrolase
  • Synonyms
    gamma-GH
  • Feature Type
    protein coding gene
  • IDs
    MGI:1329035
    NCBI Gene: 14590
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:20041963-20066111 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 7.79 cM, cytoband A3-A5
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    904 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1329035
 protein coding gene Chr4:20041963-20066750 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028087
 protein coding gene Chr4:17056095-17079958 (+)
A/J MGP_AJ_G0028045
 protein coding gene Chr4:16596832-16623362 (+)
AKR/J MGP_AKRJ_G0028010
 protein coding gene Chr4:16960765-16986835 (+)
BALB/cJ MGP_BALBcJ_G0028056
 protein coding gene Chr4:16577780-16602936 (+)
C3H/HeJ MGP_C3HHeJ_G0027786
 protein coding gene Chr4:17070623-17095452 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028499
 protein coding gene Chr4:17754420-17781863 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025841
 protein coding gene Chr4:15372176-15395921 (+)
CAST/EiJ MGP_CASTEiJ_G0027241
 protein coding gene Chr4:16893557-16921758 (+)
CBA/J MGP_CBAJ_G0027759
 protein coding gene Chr4:18268923-18297368 (+)
DBA/2J MGP_DBA2J_G0027902
 protein coding gene Chr4:16414272-16439856 (+)
FVB/NJ MGP_FVBNJ_G0027868
 protein coding gene Chr4:16140076-16164467 (+)
LP/J MGP_LPJ_G0028011
 protein coding gene Chr4:17109250-17135054 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027901
 protein coding gene Chr4:19323191-19349412 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028558
 protein coding gene Chr4:16860101-16885201 (+)
PWK/PhJ MGP_PWKPhJ_G0026961
 protein coding gene Chr4:16320903-16347464 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026790
 protein coding gene Chr4:16735161-16762465 (+)
WSB/EiJ MGP_WSBEiJ_G0027318
 protein coding gene Chr4:16897382-16923496 (+)



Homology
more
  • Human Ortholog
    GGH, gamma-glutamyl hydrolase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GGH, gamma-glutamyl hydrolase
  • Synonyms
    GATD10, GH
  • Links
    NCBI Gene ID: 8836
    neXtProt AC: NX_Q92820
    UniProt: Q92820

  • Chr Location
    8q12.3; chr8:63014881-63039407 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    800
  • Tissues
    94
  • cDNA Data
    43
  • Literature Summary
    2
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14590 NCBI Gene Model | MGI Sequence Detail 24149 C57BL/6J ±  kb
    transcript NM_010281 RefSeq | MGI Sequence Detail 1340 C57BL/6  
    polypeptide Q9Z0L8 UniProt | EBI | MGI Sequence Detail 317 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      Genomic 1
      cDNA 43

      Microarray probesets 4
    References
    more
    • Summaries
      All 34
      Developmental Gene Expression 2
      Gene Ontology 7
      Phenotypes 7
    • Earliest
      J:50477 Esaki T, et al., Cloning of mouse gamma-glutamyl hydrolase in the form of two cDNA variants with different 5' ends and encoding alternate leader peptide sequences. Gene. 1998 Sep 28;219(1-2):37-44
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory