Il18bp MGI Mouse Gene Detail - MGI:1333800 - interleukin 18 binding protein

Symbol

Il18bp
Name

interleukin 18 binding protein
Synonyms

Igifbp, IL-18BP, MC54L

Feature Type

protein coding gene
IDs

MGI:1333800
NCBI Gene: 16068
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr7:101664092-101667897 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 54.71 cM, cytoband F1
Mapping Data

3 experiments

SNPs within 2kb

123 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1333800	protein coding gene	Chr7:101664092-101669699 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0032596	protein coding gene	Chr7:105041240-105044316 (-)
A/J	MGP_AJ_G0032572	protein coding gene	Chr7:102363181-102366257 (-)
AKR/J	MGP_AKRJ_G0032508	protein coding gene	Chr7:104814885-104817961 (-)
BALB/cJ	MGP_BALBcJ_G0032583	protein coding gene	Chr7:102057593-102060669 (-)
C3H/HeJ	MGP_C3HHeJ_G0032297	protein coding gene	Chr7:105183086-105186136 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0033080	protein coding gene	Chr7:109007344-109010420 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030074	protein coding gene	Chr7:104719682-104722791 (-)
CAST/EiJ	MGP_CASTEiJ_G0031623	protein coding gene	Chr7:96748325-96751399 (-)
CBA/J	MGP_CBAJ_G0032263	protein coding gene	Chr7:112769561-112772611 (-)
DBA/2J	MGP_DBA2J_G0032415	protein coding gene	Chr7:100688767-100691817 (-)
FVB/NJ	MGP_FVBNJ_G0032371	protein coding gene	Chr7:100475487-100478563 (-)
LP/J	MGP_LPJ_G0032504	protein coding gene	Chr7:106356270-106359346 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032405	protein coding gene	Chr7:114095007-114098083 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033102	protein coding gene	Chr7:104081912-104084988 (-)
PWK/PhJ	MGP_PWKPhJ_G0031341	protein coding gene	Chr7:93803759-93806809 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0031185	protein coding gene	Chr7:91383650-91386659 (-)
WSB/EiJ	MGP_WSBEiJ_G0031740	protein coding gene	Chr7:104771776-104774852 (-)

Human Ortholog

IL18BP, interleukin 18 binding protein

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL18BP, interleukin 18 binding protein
Synonyms

FVH, IL18BPa
Links

HGNC:5987

NCBI Gene ID: 10068

neXtProt AC: NX_O95998

UniProt: O95998
Chr Location

11q13.4; chr11:71998613-72008200 (+) GRCh38

MGI Vertebrate Homology

Il18bp stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: IL18BP
Gene Tree

Il18bp

Diseases

2 with human IL18BP associations

				Human Disease	Mouse Models
				allergic contact dermatitis IDs allergic contact dermatitis DOID:3042 ICD10CM:L23 MESH:D017449 NCI:C26998 UMLS_CUI:C0162820
				myocardial infarction IDs myocardial infarction DOID:5844 EFO:0000612 ICD10CM:I21 MESH:D009203 NCI:C27996 OMIM:608557 UMLS_CUI:C0027051

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

24 phenotypes from 2 alleles in 2 genetic backgrounds
25 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

11
Chemically induced (other)

1
Endonuclease-mediated

5
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Il18bp
Incidental Mutations

APF
Find Mice (IMSR)

14 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous knockout affects NK cell differentiation and function, with an increase in immature cells and a decrease in mature cells.

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All GO Annotations

9
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

736
Tissues

6
cDNA Data

29
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

55
RefSeq

10
UniProt

3
CCDS

CCDS21522.1

Ensembl

ENSMUSG00000070427 (Evidence)
NCBI Gene

16068

			Length	Strain/Species	Flank
genomic	ENSMUSG00000070427	Ensembl Gene Model \| MGI Sequence Detail	3806	C57BL/6J	± kb
transcript	ENSMUST00000209368	Ensembl \| MGI Sequence Detail	2596	Not Applicable
polypeptide	ENSMUSP00000148201	Ensembl \| MGI Sequence Detail	194	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000008986 interleukin-18-binding protein

(term hierarchy)
InterPro Domains

IPR007110 Immunoglobulin-like domain

IPR036179 Immunoglobulin-like domain superfamily

IPR013783 Immunoglobulin-like fold

IPR039681 Interleukin-18-binding protein
GlyGen

Q9Z0M9 4 sites

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All nucleic 30

cDNA 30

Microarray probesets 3

Summaries

All 55

Developmental Gene Expression 2

Gene Ontology 5

Phenotypes 25
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:353090 Mertens RT, et al., A metabolic switch orchestrated by IL-18 and the cyclic dinucleotide cGAMP programs intestinal tolerance. Immunity. 2024 Jun 19;

TSS for Il18bp:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr73903	Chr7:101668758-101668765 (-)	-865 bp
Tssr73902	Chr7:101668732-101668747 (-)	-843 bp
Tssr73901	Chr7:101668698-101668723 (-)	-814 bp
Tssr73900	Chr7:101667429-101667446 (-)	459 bp
Tssr73899	Chr7:101667346-101667413 (-)	517 bp
Tssr73898	Chr7:101666860-101666878 (-)	1,028 bp
Tssr73897	Chr7:101666837-101666857 (-)	1,050 bp
Tssr73896	Chr7:101665352-101665364 (-)	2,539 bp
Tssr73895	Chr7:101665329-101665351 (-)	2,557 bp
Tssr73894	Chr7:101665015-101665040 (-)	2,869 bp
Tssr73893	Chr7:101664890-101664905 (-)	2,999 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24