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S1pr3 Gene Detail
Summary
  • Symbol
    S1pr3
  • Name
    sphingosine-1-phosphate receptor 3
  • Synonyms
    Edg3, LPb3, S1P3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1339365
    NCBI Gene: 13610
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:51562675-51576833 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 26.12 cM, cytoband B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    470 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1339365
 protein coding gene Chr13:51562654-51576833 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020549
 protein coding gene Chr13:50605137-50619295 (+)
A/J MGP_AJ_G0020503
 protein coding gene Chr13:48821546-48835721 (+)
AKR/J MGP_AKRJ_G0020481
 protein coding gene Chr13:50215985-50230168 (+)
BALB/cJ MGP_BALBcJ_G0020499
 protein coding gene Chr13:49017647-49031875 (+)
C3H/HeJ MGP_C3HHeJ_G0020299
 protein coding gene Chr13:50045149-50059561 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020933
 protein coding gene Chr13:52174708-52188881 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018515
 protein coding gene Chr13:46624762-46639185 (+)
CAST/EiJ MGP_CASTEiJ_G0019812
 protein coding gene Chr13:50003001-50019366 (+)
CBA/J MGP_CBAJ_G0020258
 protein coding gene Chr13:54209849-54224030 (+)
DBA/2J MGP_DBA2J_G0020381
 protein coding gene Chr13:48391137-48405835 (+)
FVB/NJ MGP_FVBNJ_G0020360
 protein coding gene Chr13:47825255-47839633 (+)
LP/J MGP_LPJ_G0020457
 protein coding gene Chr13:50877710-50891849 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020389
 protein coding gene Chr13:53801124-53815278 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020976
 protein coding gene Chr13:49774565-49788728 (+)
PWK/PhJ MGP_PWKPhJ_G0019569
 protein coding gene Chr13:48313182-48327472 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019396
 protein coding gene Chr13:48673596-48705609 (+)
WSB/EiJ MGP_WSBEiJ_G0019874
 protein coding gene Chr13:50072041-50087520 (+)



Homology
more
  • Human Ortholog
    S1PR3, sphingosine-1-phosphate receptor 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    S1PR3, sphingosine-1-phosphate receptor 3
  • Synonyms
    bA791O21.3, C9orf108, C9orf47, EDG-3, EDG3, LPB3, S1P3
  • Links
    NCBI Gene ID: 1903
    neXtProt AC: NX_Q99500
    UniProt: Q99500

  • Chr Location
    9q22.1; chr9:88990863-89005155 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 4 alleles in 5 genetic backgrounds
    31 phenotypes from multigenic genotypes
    6 images
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display an essentially normal phenotype although litter sizes are reduced. Susceptibility to pulmonary edema is also reduced.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    21
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1005
  • Tissues
    212
  • cDNA Data
    67
  • Literature Summary
    21
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000067586 Ensembl Gene Model | MGI Sequence Detail 14159 C57BL/6J ±  kb
    transcript ENSMUST00000087978 Ensembl | MGI Sequence Detail 4463 Not Applicable  
    polypeptide ENSMUSP00000085293 Ensembl | MGI Sequence Detail 378 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 77
      cDNA 69
      Primer pair 7
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2145186
    References
    more
    • Summaries
      All 130
      Developmental Gene Expression 21
      Gene Ontology 9
      Phenotypes 77
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory