Nup160 MGI Mouse Gene Detail - MGI:1926227

Symbol

Nup160
Name

nucleoporin 160
Synonyms

2810011M03Rik, Gtl1-13

Feature Type

protein coding gene
IDs

MGI:1926227
NCBI Gene: 59015
Alliance

gene page
Transcription Start Sites

3 TSS

Sequence Map

Chr2:90507559-90566672 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 50.32 cM, cytoband E1
Mapping Data

4 experiments

SNPs within 2kb

1200 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1926227	protein coding gene	Chr2:90504405-90570217 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026130	protein coding gene	Chr2:91947218-92007785 (+)
A/J	MGP_AJ_G0026091	protein coding gene	Chr2:88279973-88340185 (+)
AKR/J	MGP_AKRJ_G0026072	protein coding gene	Chr2:90722352-90783842 (+)
BALB/cJ	MGP_BALBcJ_G0026100	protein coding gene	Chr2:88435536-88495271 (+)
C3H/HeJ	MGP_C3HHeJ_G0025851	protein coding gene	Chr2:90995032-91058332 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0026551	protein coding gene	Chr2:95182063-95246304 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0023941	protein coding gene	Chr2:84798157-84862375 (+)
CAST/EiJ	MGP_CASTEiJ_G0025316	protein coding gene	Chr2:91502532-91563318 (+)
CBA/J	MGP_CBAJ_G0025829	protein coding gene	Chr2:98424557-98491220 (+)
DBA/2J	MGP_DBA2J_G0025965	protein coding gene	Chr2:87879207-87938397 (+)
FVB/NJ	MGP_FVBNJ_G0025928	protein coding gene	Chr2:86975547-87035663 (+)
LP/J	MGP_LPJ_G0026069	protein coding gene	Chr2:92152877-92217364 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0025954	protein coding gene	Chr2:101488086-101548439 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0026605	protein coding gene	Chr2:90770025-90830986 (+)
PWK/PhJ	MGP_PWKPhJ_G0025051	protein coding gene	Chr2:87597744-87658586 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0024852	protein coding gene	Chr2:90356920-90420415 (+)
WSB/EiJ	MGP_WSBEiJ_G0025383	protein coding gene	Chr2:91350317-91414512 (+)

Human Ortholog

NUP160, nucleoporin 160

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

NUP160, nucleoporin 160
Synonyms

NPHS19
Links

HGNC:18017

NCBI Gene ID: 23279

neXtProt AC: NX_Q12769

UniProt: Q12769
Chr Location

11p11.2; chr11:47778087-47848555 (-) GRCh38

MGI Vertebrate Homology

Nup160 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: NUP160
Gene Tree

Nup160

Diseases

1 with human NUP160 associations

				Human Disease	Mouse Models
				nephrotic syndrome type 19 IDs nephrotic syndrome type 19 DOID:0080394 OMIM:618178

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

13
Radiation induced

1
Targeted

3
Genomic Mutations

4 involving Nup160
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

64 strains or lines available

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All GO Annotations

18
GO References

8

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

116

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase nup160

ZFIN nup160

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All Sequences

59
RefSeq

13
UniProt

1
CCDS

CCDS16413.1

Ensembl

ENSMUSG00000051329 (Evidence)
NCBI Gene

59015

			Length	Strain/Species	Flank
genomic	ENSMUSG00000051329	Ensembl Gene Model \| MGI Sequence Detail	59114	C57BL/6J	± kb
transcript	ENSMUST00000057481	Ensembl \| MGI Sequence Detail	5684	Not Applicable
polypeptide	ENSMUSP00000059289	Ensembl \| MGI Sequence Detail	1402	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000011510 nuclear pore complex protein Nup160

(term hierarchy)
InterPro Domains

IPR021717 Nucleoporin Nup120/160
GlyGen

Q9Z0W3 1 site, 1 O-linked glycan (1 site)

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All nucleic 118

cDNA 117

Other 1

Microarray probesets 4

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MGI:1917661, MGI:2138773, MGI:2139185

Summaries

All 48

Gene Ontology 8

Phenotypes 14
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:301567 Sakuma S, et al., Inhibition of Nuclear Pore Complex Formation Selectively Induces Cancer Cell Death. Cancer Discov. 2021 Jan;11(1):176-193

TSS for Nup160:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr18759	Chr2:90507552-90507580 (+)	7 bp
Tssr18760	Chr2:90509713-90509756 (+)	2,176 bp
Tssr18761	Chr2:90563083-90563102 (+)	55,534 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24